| The main products of a Jiangxi pharmaceutical company are antibiotic series of API and pharmaceutical intermediates. At present, the main products are tazobactam acid, sulbactam acid, meropenem and intermediates, imipenem, ertapenem, etc. The wastewater has the characteristics of high COD, high nitrogen, high phosphorus, high sulfuric acid root, high salinity, high chromaticity and large toxicity, complicated composition, degradation-resistant, etc. This study used the physico-chemical pretreatment method of MAP precipitation+CaO desulfurization+Fe-C+Fenton to treat the high concentrated wastewater of pharmaceutical intermediates, after the pretreatment effluent mixed with low concentration wastewater the mixed wastewater will be treated by biochemical method, the final effluent should meet the take over standards of the sewage treatment plant in the pharmaceutical industrial park.The physical and chemical pretreatment technology of pharmaceutical intermediates wastewater was studied. The wastewater was experimented with the combination physico-chemical pretreatment process of MAP precipitation+CaO desulfurization+Fe-C+Fenton. After the experiment the optimum reaction conditions and the operation parameters were confirmed. The physical and chemical pretreatment combination process technology was used in engineering practice. The engineering was designed and operated with the optimum reaction conditions and the operation parameters from the experiment. The research results show that:(1) Pharmaceutical intermediates wastewater was treated by MAP denitrification and dephosphorization experiment, when the temperature is 20℃, the reaction pH is 9.0, the Mg/N rate is 1.2:1.0, the precipitation reaction time is 1h, at the moment the removal rate of ammonia nitrogen and phosphorus was highest which were 92.2% and 99.7% respectively.(2) Pharmaceutical intermediates wastewater was treated by CaO desulfurization experiment, through the experimental analysis, the optimum reaction time is 4h, precipitation time is 1 h. The sulfuric acid root concentration of influent is 62085mg/L The additive amount of CaO was controlled to 36.7g/L. The removal rate of sulfate is 86.8%, the residual sulfuric acid root concentration is 8220mg/L.(3) Pharmaceutical intermediates wastewater was treated with the combination process of Fe-C+Fenton, with the 1:1 ratio of Fe/C packing, the optimum pH of Fe-C micro-electrolysis experiment is 3.0, the optimum reaction time is 120 minutes. The CODCr removal rate is 26.1%. The wastewater after Fe-C micro-electrolysis reaction reacted with 30% H2O2, the optimum reaction pH is 3.0, the optimum reaction time is 180 minutes, the best H2O2 dosage is 10ml/L, the CODCr removal rate is 23.5%. Under the optimum reaction conditions, the CODCr removal rate with the combination of Fe-C+Fenton process is about 49%. The biological rate of BOD5/CODCr rose from 0.09 to 0.41, which improved the biological ability of the wastewater greatly.(4) According to the results of experimental study, the physical and chemical pretreatment combination technology was able to meet the expected treatment effect, which removed most of high concentration of ammonia nitrogen, phosphorus and sulfuric acid root in pharmaceutical intermediates wastewater, which also removed part of COD and improved the wastewater biological ability much better. The engineering was reformed and put into operation according to the experiment results. The original wastewater treatment engineering will be modified to ensure that the final drainage meet the standard. |
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