The Preparation And Application Of Electrospun α-Cyclodextrins Pseudopolyrotaxane/Polymer Nanofibers With Core-Shell Structure

Electrospun technology is a simple but effective and inexpensive method for preparing micro- to nanosized fibers. Owing to their smaller diameters, these fibers have enormous potential in applications such as biological medicine, tissue engineering scaffold, filter materials, electronic devices, nanometer catalysis and other fields. Cyclodextrins (CDs) with cavity structure of hydrophilic exterior and hydrophobic interior are able to form host-guest inclusion complexes with a variety of molecules such as organic, inorganic, polymer and metal particles by the non-covalent interactions. So that, the researches in application field of cyclodextrins and its supramolecular chemistry have gradually increased. In this study, cyclodextrin molecules were orderly loaded on the surface of the nanofibers by the combination of electrospun and self-assembly method.Firstly, cyclodextrin pseudopolyrotaxane with highly ordered arrangement of cyclodextrins were successfully prepared, and this structure was anchored on the polymer nanofibers surface of polyacrylonitrile (PAN) and polyoxyethylene (PEO), respectively. The preparation, characterization and adsorption properties of the nanofibers were explored.Research contents and conclusions were listed as follows:1、 The cyclodextrin pseudopolyrataxane (α-CD-PEG-PPR) with "Channel-type" crystal structure was prepared by co-precipitation method, using cyclodextrin (α-CD) and polyethylene glycol (PEG) as raw materials. And then, its structures were characterized by using XRD、TGA、1HNMR.2、α-CD-PEG-PPR/PEO composite nanofibers with core-shell structure were successfully prepared by homogeneous electrospun solution. In vitro cytotoxicity test results showed that the fiber membrane has good biocompatibility, and has good application prospects in the field of biomedical materials.α-CD-PEG-PPR/PAN core-shell structure composite nanofibers also were prepared by the same method. SEM and TEM were used to analysis the effect of the different weight ratio of α-CD-PEG-PPR to PAN, receiving distance and spinning voltage on the nanofiber morphology and the diameter of the fiber and the core-shell structure. On the basis of the characterization of biocompatibility, using phenolphthalein (PhP) as model compound, the adsorption capacity of α-CD-PEG-PPR/PAN fiber membrane was investigated by UV-vis spectrometry. The adsorption capacity of α-CD-PEG-PPR/PAN fiber membrane increased with the ratio of α-CD-PEG-PPR in composite fiber membrane, the decrease of PhP concentration was significant after 24h (in the range of ～25%-40% depending on the α-CD-PEG-PPR content), the maximum absorption of nanofibers reached 90% after 7 day. The results demonstrate that α-CD-PEG-PPR/PAN nanofibers have a great application potential in filtration membrane, purification and separation processes for some organic molecules.