The Synthesis Of Imidazopyridine Pharmaceutical Intermediates

Antibacterial agents are bactericidal or bacteriostatic activity of drugs, which can cure the infectious diseases caused by bacteria, fungi, etc. These drugs are widely used in modern clinical medicine. At present, with the development of economic, the production and using of antimicrobial agents has become more and more widely. Combined with the runaway in clinical application of antibacterial agents, including the two aspects of prevention and treatment, which has made bacterial drug resistance increasing year by year. So, new antibacterial drugs research and development is of great significance in present and future.In the process of the synthesis of new antibacterial drugs, the synthesis of pharmaceutical intermediates shows more and more important position. Based on the classical Pinner reaction, this paper explores a more moderate and efficient way to implement in the same molecule in the presence of amide groups introduce carboxylic acid groups, and then synthesis for a class of imidazopyridine pharmaceutical intermediates containing the two functional groups at the same time. Finally, we characterized the structure of the pharmaceutical intermediates through NMR, LC-MS and so on. The breakthrough of this reaction has laid a good foundation for the next synthesis of a class of antibacterial drugs.