Benzimidazole Iodized Salt Reaction

Based on the one-carbon unit transfer reaction of tetrahydrofolate coenzymes, in previous papers, we reported the addition-hydrolysis reaction of benzoimidazole methiodide salts with nucleophiles such as Grignard regents and ethyl malonate, and the new methods for the preparation of aldehydes, ketones and ^-keto acid were provided. In this paper, two new reactions of benzoimidazole methiodide salt with amine nucleophiles and nitromethane anion were studied, and a novel method for the biomimetic synthesis of many compounds was presented. Benzoimidazole methiodide salt was used as tetrahydrofolate coenzyme model at formic acid oxidation level and amine compounds, nitromethane anion as nucleophiles to which one-carbon unit was transferred.The addition-hydrolysis reaction of benzoimidazole methiodide salt with some mono- and bi-functional amine nucleophiles was studied, and a new addition-hydrolysis reaction of benzoimidazole methiodide salt with amine compounds and a new method of biomimetic synthesis for formamides and heterocycle compounds were provided.One -nitroaldehyde and two a -nitroketones were prepared by the addition-hydrolysis reaction of three kinds of benzoimidazole methiodide salts with nitromethane anion, and a new addition-hydrolysis reaction of benzoimidazole methiodide salt with nitromethane anion and a new method of biomimetic synthesisfor -nitroaldehyde and a -nitroketones were provided.n-Butanal was synthesized by the addition-hydrolysis reaction of benzoimidazole methiodide salt with Grignard reagent, and a new method of biomimetic synthesis for n-butanal was provided.In this paper the mechanisms and influences of reaction conditions on the yield were discussed in detail.