Cyclopropylamine Synthesis

The usage research background and main routes of synthesizing cyclopropylamine was introduced in this paper. The advantages and the disadvantages of every synthesizing route were analyzed briefly, and the synthesis of cyclopropylamine was studied. Cyclopropylamine was synthesized by five steps which were ring opening ,ring closure, hydrolysis and transforming to acid amide and Hoffmann degradation. The intermediate productions were iso-propyl- γ -chlorobutyrate, cyclopropanecarboxylic acid isopropyl, cyclopropanecarboxylicacid and cyclopropanecarboxamide. The whole yield is 48.7%.These synthetics were qualitatively analysized and quantitatively analysized by using traditional titration and modern analytical methods (IR, GC, NMR) .