Coronary Danshen Capsule Preparation Process And Quality Standards

Fufangdanshen capsule,which is made from Chinese herdal medicines,has many efficiencies ,such as activating the blood ,reducing phlegm,qi regulating and assuage pain,it used to tread feeling of oppression in the chest , palpitation, shortness of breath,stagnation of chest Qi,At this the researches of subject,the experimental study has been carried out on its preparation and quality standard.Study on the preparationRadix Salvisa Miltiorrhiza:Using the transferring rate of tanshinone II a , Danshensu-Sodium and extract ration as indexes,we selected the optimum extraction condition with alcohole by orthogohal test which selects alcohole content,alcohole volume,extracting as factors,the optimum alcohole extracting condition is:whit 90%Ethol as a solvent,reflux extracting two times,adding 10 times solvent volume ,extracting one and half hours, dregs of a decoction selected the optimum extraction condition with water by the orthogohal test which selects extracting times, water volume, abstracted time as factors,the optimum extracting condition is:with reflux extracting three times,adding 10 times solvent volume ,extracting two hours, concentrating to relative density at 1.15 ,Sinking desity by ethanol(95% to 60%),still 24 hours.Radix Notoginseng: Using the transferring rate of Ginsensoside Rb1,R1,Rg1 and extract ration as indexes,we selected the optimum extraction condition with alcohole by orthogohal test which selects alcohole content,alcohole volume,extracting as factors,the optimum alcohole extracting condition is: with 90% Ethol as a solvent,reflux extracting two times,adding 10 times solvent volume extracting one and half hours,one hours.Lignum Dalbergiae Odoriferae: the optimal process for oil extraction was adding 6-fold water in 40(sieve number) of fragmentation, immersion 12 hours and distilling for 5 hours. β-C Dinclusion compound of volatile oil being 12:l,the inclusion compound being stirred for 3 hours at 50 °C.Selecting microcrystation cellulose, colloidal silicon dioxide ,CMS-Na,starch microspheres as capsule excipient,to observe these humidity absorption and fluidity of the powders, microcrystation cellulose- colloidal silicon dioxide(l:2), the rate of humidity absorption is the lowerest, fluidity of the powders is in effective site.study on quality standardRadix Salvisa Miltiorrhiza, Radix Notoginseng Lignum Dalbergiae Odoriferae were indentified by TLC,the quantitative determination of Ginsensoside Rb1, Rg1, Notoginsensoside R1, ,Tanshine II A ,Danshensu-Sodium were determinated by HPLC,the method had good repeat ability,sensitivity and specificity.