Xinnuo Kang Capsule Preparation Process And Quality Standards Study

Coronary heart disease is the disease that seriouly endangers human health. It's occurrance ranks first among all variour discases in Europe and USA, while it's occurance and death rate remain high all the time in latest 30 years. The rate still continue to increase with the llonger life expectancy and the agin of population. So, currently, most urgent task for the pharmacists to control the development of the disease.Xinnuokang capsules, which is made from Radix Astragali,Valeriana officinalis L and Radix Salviae Miltiorrhizae, is an effective prescription of traditional Chinese medicine for treating Coronary heart disease. The author had made an expriment study on its preparation, quality standards.1. study of the preparationRadix Astragali: Applying the L₉(3⁴) of orthogonal design. The condition of water extraction is determined form the Astragalus methylgiucoside (factor: dosage and extraction time, extraction frequency). Optimum processing condition is as follows: 8 times as extraction dosage, 1 hours as macerated time, and extraction third: 2 hours every time.Valeriana officinalis L.: To screen out an optimum extraction technology of volatile oil from Valeriana offiCinalis L. Test was carried out to compare two extraction effects between two different distillations by detecting the extraction ratio of Valeriana officinalis L. With the quantity and capacity ofβ-cyelodextrin(β-CD), Taking the optimum preparation conditions forβ-CD of Valeriana officinalis L.Radix Salviae Miltiorrhizae: Applying the L₁₈ (3⁷) of reflux-alcohol extraction (factor: content of TanshinoneⅡ_A as the mark, the terms of dosage and concentration of alcohol, extraction time, extraction frequency) can be decided. Optimum processing condition is as following: 4 times as extraction dosage, 70% as extraction concentration, 1 hours as macerated time, and extraction third: 1 hour every time.Research on formation technology: Investigated the mosisture absorption and fluidity of power after mixed with the differ excipient.2. study of quality standardRadix Astragali,Valeriana officinalis L., Radix Salviae Miltiorrhizae were identified by TLC, the content of Astragalus methylglucoside which is the effective element in the preparation and the medicinal material was determined as the index by HPLC. The quality control is feasible and can be applied to control the products from mass production. It can be ensured the stability of the product's quality.