Freckle Capsule Preparation Process And Quality Standards

QuBan Capsule is a compond preparation developed according to a prescription, which had been tested in clinic. It consists of Radix Paeoniae Rubra.Radix Angelicae Sinensis and so on. QuBan Capsule is beneficial for treating chloasma and has the effect of removing blood stasis to promote circulation, clear the heat of liver, nourish the spleen and arrest sweating. The author has studied on its preparation process and quality standards.1. Study on the preparationIn accordance with properties of the herbs of the prescription and the need in the clinic, the capsules were selected as the dosage form of the drug. To optimize the extraction by several orthogonal tests. Using the content of Paeoniflorin as indexes, the optimum extracting condition with alcohol of Radix Paeoniae Rubra and Semen Celosiae was made, that was adding 70% alcohol 8 times, extracting 3 times for 0.5 hours per time. Using the degree of volatile oil collection as indexes, the extracting condition of Radix Angelicae Sinensis and Rhizoma Atractylodis Macrocephalae was adding water with 5 times, extracting 6 hours. Choosing several indexes to get the optimum inclusion conditions of volatile oil, the best condition was oil and β -CD with a ratio of 1:8, the temperature is 40℃ and the time is 1.5 hours. Using the content of polysaccharide as indexes, determine the optimum exacting conditions of Poria was adding water with 8 times, decocting 3 times for 1.5 hours per time.The moulding process is determined by parrl test according to the rate of hygroscopicity and fluidity. Choosing 10% powder of Poria as the adjuvant, mixed the dry paste and the powder. The package was 0.44 gram for each capsule.2. Study on quality standardRadix Paeoniae Rubra and Radix Angelicae Sinensis were indentified by TLC. The spot develops were fairly clear, and the blank test showed no interference. Using HPLC to determine Paeoniflorin content, and the reach of method was carried out.