Some Methyl Substituted The Synthesis, Characterization And Properties Of Modified Cucurbituril

Q[n]s have poor solubility in commonly used solvent which hamper the development of Q[n]s. Many research group seek to synthesize substituted Q[n]s which with good solubility. Recently, a number of substituted Q[n]s have been reported. Institute of Applied Chemistry of Guizhou University has Synthesized a number of substituted Q[n]s and Q[n], and has done a lot of basal work. These offer a very good opportunity for further study of substituted Q[n] that its importance not only achieves a new substituted Q[n] with ready solubility, but also gives a new route to substituted Q[n]. The most important facet is the way that adds specific group in certain location of Q[n]'s. Then we may bring cucurbiturils into practical application.Firstly, synthesis of a unsymmetrical methylsubstituted cucurbit[5,6]uril (PMeQ[5] and HMeQ[6]) has been achieved by using the monomethylsubstituted glycoluril. By crystallizing again and again, partially methylsubstituted cucurbit[5]uril (PMeQ[5]) have been achieved; partially methylsubstituted cucurbit[6]uril (HMeQ[6]) have also been isolated by adding dioxane to the complex solution. During the course of separation, crystal of PMeQ[5] and the crystal of interaction compound of HMeQ[6] and dioxane has been achieved, this crystal is analyzed by single crystal X-ray diffraction.Secondly, different kind of detective techniques have been employed including ¹HNMR,¹³CNMR and MS for characterize PMeQ[5] and HMeQ[6]'s structure.Furthermore ,we measured the PMeQ[5] and HMeQ[6]'s solubility in commonly used solvents, the study show that PMeQ[5] and HMeQ[6] both have good solubility in aqua, and reasonable solubility in some organic solvents. Investigation into interactive chemical between HMeQ[6] and some organic guest molecules has been carried out...