| Nuanxin capsule was made from Red Ginseng, Cooked Prepared Common Monkshood Daughter Root, Ma-yuen Jobstears Seed and Tangerine Red Epicarp. Its effects include benefiting vital energy, warm core, activating yang and absorbing clots. It can be used for diastolic heart failure in clinical.To investigate the extraction process, Purification process, preparation shaping technology and quality control technology.1. To design the extraction technological line according to the physico-chemical property of the effective constituents.Ultrasonic extracting method was selected with the Single-factor experiment which made the ginsenoside Rgl content as the target. Orthogonal experiment was used to study the best method of extraction condition with naringin contents.The optimize is that,75% alcohol,six folds solvents of the crude drug weight and ultrasound extracted 25 minutes for two times.2. To study the optimal condition by the macroporous resin purificating process with he Elution index of ginsenoside Rgl. The type of macroporous resin is DM130.the concentration of column-loading buffer is 0.2/mL,3 BV/min,50% alcohol and pH is 7.0. The proportion of eluant and crude drug was 20:3(V/W). The elution rate of ginsenoside Rgl and naringin could reach to 81.4% and 78.7%.3. To study the shaping technology of Nuanxin Capsules systematically.Through the observation of pass rate and moisture rate, the formula is that,dryextract:accessories is 3:1 (starch soluble:dextrin is 7:1 in the accessories). The wetting agent is 90% alcohol and use wet granulation method.4. To study the quality control of Nuanxin Capsules. Ma-yuen Jobstears Seed and Tangerine Red Epicarp are qualitative analysis with thin-layer chromatography (TLC); Red ginseng and Cooked Prepared Common Monkshood Daughter Root are quantitative analysis by high-pressure liquid chromatography (HPLC).This method is faster, easier and specificity.It is very useful for quality control.
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