Clear Gold And Asthma Particle Preparation Process, Quality Standards And Pharmacodynamic Preliminary Study

Bronchial Asthma is a kind of commonly-seen clinical disease which frequently occurs in recent years, both of whose morbidity and mortality have an uptrend. It is one of the major diseases that has been seriously threatening people physically and mentally. Chinese medicine has long been used for the treatment of asthma and the employment of traditional Chinese medicine can produce good effects, minimize side effects, be good at prevention and longer the cure advantages. Therefore, in the prevention and treatment of asthma, Chinese medicine plays an irreplaceable role. Sangbaipi Decoction is the representative of the prescriptions to asthma. This prescription is reasonable, and the clinical efficacy is quite good. This paper makes a tentative study on this prescription from the perspectives of the preparation of drugs and the quality standards for research and establishes a reasonable production line and a controllable quality standard. And in order to make sure that mass production is feasible, a preliminary test for Sangbaipi soup will be made portable to check the pharmacodynamics of this prescription, convenient and controllable.This study mainly includes the following three aspects:1. The study of the preparation step: using the orthogonal design with high-performance liquid chromatography, titration, gas chromatography and other means of berberine, baicalin, amygdalin,α-methyl for flax Determination of optimum indicators of alcohol extraction, water extraction, andβ-cyclodextrin inclusion in the best of conditions.2. The study of the Quality Standard: using berberine and baicalin for quantitative indicators. Using Tendrilleaf Fritillary Bulb ,Sangbaipi, Banxia, Gardenia, Bitter Apricot Seed for qualitation .3. The tentative study of the efficacy: In accordance with the functions of this prescription, the experiments of a mouse model of asthma is to be made to observe histologically in the lungs, count SOD, MDA Detection. The results showed that the asthma-particles can inhibit inflammatory exudation, reducing airway inflammation.