Effect Of Moxibustion On The Gc Signal Pathway In Synoviocyte Of Experimental Ra

Objective:Observe the influence of GC pathway's signal transduction in RA synovial cell of experimental rabbits by moxibustion,and reveal the anti-inflammatory molecular signal mechanism of experimental RA by moxibustion.Methods:Apply gene chip and bioinformation analytical technique to detect the 36 sorts of signal molecule of GC pathway.Results:Compare model group with normal group, GC pathway has been activated abnormally, and as a result, the expression of proinflammatory signal molecules has been up-regulated; compare moxibustion group with model group, the expression of some anti-inflammatory signal molecules has been up-regulated, while some signal molecules showed no significant increases or reduction(Results are not statistically significant), however, the expression of some anti-inflammatory signal molecules show an upward tendency, and the expression of some proinflammatory signal molecules show an downward tendency.Conclusions:Moxibustion plays an important roll in regulating GC pathway's signal transduction in RA synovial cell of experimental rabbits. Maybe this is an important mechanism of Moxibustion playing anti-inflammatory effect.