The Curative Effects On Treatment Of Recurrent Genital By Huangbaiye And Effect On Toll-like Receptors

Objective:To investigate the clinical significance and mechanism of Huangbaiye in preventing and curing the Recurrent genital herpes(RGH). To explore the expressions of Toll-like receptors(TLRs) on CD 14+ monocytes and the roll in the pathogenesis of RGH by Huangbaiye.Method:The 90 patients were randomly divided into 3 groups completely. 30 were treated with Famciclovir.30 were with Huangbaiye.30 were with Huangbaiye combined Famciclovir. Observed the integral of clinical symptoms, clinical efficient rate, and the recurring rate respectively before and after the treatment, also checked the change of TLR4 and TLR1, and compared with 10 normal person.Results:1. The integral of clinical symptoms were improved obviously after theatment for three groups.There was no significant difference in clinical rate for another three groups. The group treated with Huangbaiye combined Famciclovir showed a lower recurring rate than other groups.2. The expression of TLR4 on CD14+ monocytes was significantly higher in patients with RGH than that in healthly controls(P<0.001);but TLR1 was markedly lower than that in controls(P<0.001).3. The three treatment group all could decrease the expression level of TLR4 and increase the expression level of TLRl;but Huangbaiye combined Famciclovir could regulate the expression level of Toll-like receptors(TLRs) on CD14+ monocytes as the healthy people (P>0.05).Conclusion:Huangbaiye is effective for patient with RGH. It can improve the function of immunity, also prevent the recurring of RGH combining with Famciclovir, and play a key role in recognizing virus, enhancining signal transduction and initiating innate immune responses to viral pathogens.