An Efficient Cream To Promote Healing Of Skin Ulcers

Purpose:Through the observation of Yixiao ointment on skin ulcers animal models, this paper discusses the influence and the comparative study of the Yixiao ointment on skin ulcers treatment function and mechanism for further research and , application the Yixiao ointment to provide the basis for clinical treatment of skin ulcer, ulcer treatment for skin to provide useful reference.Material and Method:Design:Using randomized controlled animal experiments.Materials:Clean level only male mice, or 54, mass 25 ~ 30g;Yixiao powders, Beifu agentia and physiological saline all by liaoning university of traditional Chinese medicine hospital pharmacy provided. Rabbit fight rats polyclonal antibody and SP, DAB show color kit all by Beijing bo orson biological technology Co., LTD. Offers.Methods: 54 mice randomly divided into group, positive control group, and model established respectively for the skin ulcers model, vitiligo patches on Yixiao ointment, positive control effect vitiligo patches on the Beifu agentia, model control group vitiligo patches on the physiological saline. Regular macroscopic observation ulcer area size, surface secretions, etc. In the dressing 12d,7d,3d, with film method for measuring the wound area, and calculate the wound back the area and shrinkage rate; Take and basal parts of the muscle tissue producer wound respectively, do regular pathology, vascular endothelial growth factor (VEGF), CD34 and the epidermal growth factor receptor (EGFR) immunohistochemistry markers expression, observe capillary vascular quantity and area is calculated.Results:The course of treatment, build mode 12d after the 7d, 3d, with positive control group were wound area and shrinkage in model control group (P<0.05). Made 12d conventional pathology revealed after modulus between three groups have difference, made after 12d,7d, immunohistochemical CD34,VEGF,EGFR markers showed the group and control group and positive, but no obvious difference between the two groups are associated with significant differences between model control group (P<0.05).Conclusion:Yixiao ointment can promote the healing of mice ulcer to treatment, improve skin ulcers skin ulcers local blood circulation, promote fibroblasts proliferation and newborn capillary formation, promote granulation tissue growth, promoting the repair, accelerate ulcer coagulant have very good effect, its function and Beifu agentia quite.