Patients With Alopecia Areata Serum Interleukin-1¦Â, Interleukin 10 And Interferon-¦Ã Levels And Clinical Analysis

Part I Clinical analysis of 118 cases of alopecia areataObjective: To investigate the clinical features of alopecia areata such as age, sex, subjective symptoms and so on, and relationships between these factors and disease severity.Methods: Clinical materials of 118 patients who were diagnosed as alopecia areata were collected. The role of sex was analyzed in the disease and the correlation between disease severity and sex, age or psychological factors were analyzed.Results: 118 patients including 101 cases of alopecia areata (AA), 5 cases of alpecia totalis (AT) and 12 cases of alopecia universalis (AU) were enrolled. The ratio of male to female was 1.2:1 and there was no correlation between sex and disease severity; The patients were from 1 to 76 years old while the average age was 31.25 1.30 years, and the female patients were 28.94 1.86, the male were 33.19 1.78; The median course was 2.5 months, while AA was 2 months , AT/AU was 18 months; 14.4% patients (17/118), including 11 cases AA and 6 cases AT/AU had subjective symptoms; 20.3% patients (24/118) had psychological factors before onset, 60.2% patients (71/118) had difficulties in sleeping, nail changes were found in 15.2% patients (18/118), and ocular symptoms were found in 5.9% patients (7/118) , 5.9% patients (7/118) had family history; 6.8% patients (8/118) were recurrent, 3.4% patients (4/118) were accompanied by disease of thyroid gland; 1.7% patients (2/118) were accompanied by vitiligo; TGA and TMA levels elevated abnormally in 4.8% patients (3/62); Those factors including psychological factors, sleeping problems, family history had nothing to do with severity of the disease.Conclusions: Alopecia areata often influences young to middle-aged people , and there is no correlation between sex and disease severity ; Female patients were younger than males; A few patients are induced by psychological factors, and some accompanied by other autoimmune diseases such as disease of thyroid gland and vitiligo.AT/AU was easier to have subjective symptoms than AA; The factors such as psychological factors , sleep disorder and family history had nothing to do with severity of the disease;...