Lean Body Mixture In Treating Children With Simple Obesity And High Islet Hyperlipidemia Clinical Studies

Objective To investigate the relationship among blood sugar, serum leptin(LP), insulin, tumor necrosis factor- a (TNF-α ) and insulin resistance(IR), plasma lipid, fatty distribution and to study the clinical therapeutic effectiveness and the mechanism of Shouti Oral Liquid in simple obesity children with hyperinsulinism.Methods 43 patients were divided randomly into treatment group (TG)(male, 15 cases; female, 7 cases, average age, 11.3±2.0 years, average progress, 5.1±2.2 years) and control group (CG) (male, 13 cases; female, 8 cases, average age, 11.0±2.4 years, average progress, 5.2±3.5 years). TG patients took Shouti Oral Liquid and CG took tab Metformin. The therapy periods are both 2 months .The plasma lipid , body fatty, insulin resistance index (IR) and some hormones related to obesity before and after therapy were measured and the changes were analysised.Results 1. The levers of the triacylglycerol (TG), LP, TNF-α , PG2h, PG3h, INS3h were much higher than normal and the fasten plasma glucose (FPG) was normal. FINS was positively correlated to the LP, TNF-α ,ffi. , waist(r=0.561,0.413,0.841,0.429. P<0. 05,0. 01) and negatively to the insulin activity index(IATXr=-0.827, P<0. 01) . The multifactor regression analysis indicated that LP and TNF-α were correlated to the IR independently. 2. The weight, F%, waist, BMI, adipose tissue depth besides belly button were all much declined than pretherapy in both group(P<0. 05, 0. 01) .especially in the TG and the difference about adipose tissue depth besides belly button between two groups was obvious(P<0. 05). The hip and VVHR were also declined than pretherapy in TG(P<0.05). 3. The TG, TC, LDL-C, LDL-C/HDL-C, LP, TNF- α , integra , integra difference of Chinese medicine scientific symptom, FINS, IR, PG2h, PG3h and INS3h were all declined than pretherapy in both group(P<0. 05,0. 01). The eight Ites in the former were more declined in the TG and the LP, integra , integra difference of Chinese medicine scientific symptom had statistic difference(P<0.05) .The latter five Ites were more declined in the OG but did not had statistic difference(P>0. 05). The IAI was higher than pretherapy (P<0. 05)and the FPG had no difference (P>0. 05). 4. The significant effect, normal effect and total efficiency were 22.7%, 59.1%, 81.8% respectively in TG and 9.5%, 52.4%, 61.9% in OG. The effect in TG was better than in OG(P<0. 05). 5. The blood routine, the function of liver and kidney and ECG did not change much in TG.Conclusion There were lipid metabolism disorder ,insulin resistance and high lever LP and TNF-α in obesity children with hyperinsulinism. The total effect using Shouti Oral Liquid was better than using control medicine and the mechanism was though regulating lipid metabolism, decreasing LP and TNF-α and ameliorating insulin resistance.