Clinical Study Of Obesity-associated Hypertension And Experimental Study On Mechanism Of Diet Induced Obesity And With Zi Niqizhutang

Background： With the speeding up of the improvement of the living standard andthe rhythm of life, obesity-associated hypertension incidence increased year by year, hasbecome a health issue of global concern，Common obesity related hypertension clinic, butits mechanism is complicated, involving many factors, there is still no convincingexplanation, so the treatment dilemma.Objective: To use the Yun Pi Sheng Qing treatment of obesity-associated hyper-tension, and to explore the effectiveness of the treatment and the changes of relevantindicators.To observe the effects of Spleen and Dampness expectorant herbs on dietinduced obesity (DIO) rat obesity, fat hormone and leptin resistance。Methods:(1) Clinical observation:Patients who are the clinical diagnosis of obesitycomplicated with hypertension and the symptoms were Pi shi jian yun were randomlydivided into experimental and control groups, the experimental group with40cases haveantihypertensive drug Valsartan Capsules together Zi Ni Qi Zhu Tang,while the controlgroup of40patients only have antihypertensive medicine Valsartan Capsules, all thepatients are taken medication for four weeks for a course, two courses of treatment.(2) Experimental study on the mechanism:120Wister rats,10as a control groupwere given the basal diet, and the remaining110were given high-fat high-nutrition diet for15weeks, according to weight, we obtained40DIO rats and10DIO-R rats. DIO rats weredivided into four groups: DIO model group, sibutramine group, dampness expectorantgroup,and spleen group, respectively by gavage of saline, sibutramine, dampnessexpectorant herbs, spleen herbs, blank control group and DIO-R group by gavage of saline.During gavage, blank control group was given the basal diet; the remaining five groupswere still given the high fat diet. Their weight, body length, and all intra-abdominal fat were examined to measure the degree of obesity and fat content after12weeks gavage.Insulin resistance index (IRI), glucose, triglycerides, cholesterol, leptin, neuropeptide Y,tumor necrosis factor (TNF-α),and adiponectin were examined in the serum. Leptin,TNF-α, adiponectin, suppressors of cytokine signaling-3(SOCS-3) and other relevantadipose hormones and inflammatory cytokines were examined in the homogenized fat.Results:(1) Clinical observation:The effective rate of experimental group (Yun PiSheng Qing group) on blood pressure improved markedly was52.5%,total effective ratewas87.5%. systolic blood pressure (SBP) and the diastolic blood pressure (DBP)significantly reduced than the control group (p <0.01); after two courses of treatment, theexperimental group had significant difference than the control group (p<0.01) on themeasurement indicators(BMI，WC,WHR); in improving the lipid profile，TG and CHOL,LDL-C, HDL-C, Lp (a) had significantly better than the control group (p <0.05p<0.01).Yun Pi Sheng Qing recipe together common antihypertensive drugs to treat40cases of PiShi Jian Yun patients with obesity-associated hypertension, effective rate of clinicalsymptoms was32.5%,the total effective rate was97.5%. Clinical safety and found noadverse reactions.(2)Experimental study on the mechanism: Compared with DIOgroup,Zi Ni Qi Zhu Tang group’s body mass index, fat coefficient and IRI decreased （P＜0.05， P＜0.01），in the serum and the homogenized fat leptin and adiponectin increased（P＜0.01）, in the serum and the homogenized fat TNF-α decreased （P＜0.05， P＜0.01）, in the homogenized fat SOCS-3decreased (P <0.01); in the serum and thehomogenized fat，dampness expectorant group’sTNF-α decreased (P <0.05)， in theserum adiponectin increased (P <0.05), in the homogenized fat leptin increased (P <0.05).Conclusion: Clinical efficacy showed that the Yun Pi Sheng Qing method of obesity-associated hypertension lowered blood pressure and lipids. Yun Pi Sheng Qing method ofobesity-associated hypertension is not only effective treatment, and is based on the basictheory of traditional Chinese, Integrated Traditional and Western treatment of obesity-associated hypertension had expanded the idea, and had the value of further study.Zi Ni QiZhu Tang can reduce weight,and TNF-α in the adipose tissue. Yun Pi Sheng Qing herbscan inhibit fat diet-induced obesity and IR, superior to dampness expectorant herbs, itsmechanism is closely related to promote fat secretion of leptin, adiponectin, reduced leptinresistance and insulin resistance.