Albicans Intravenous Infection Studies, The Pathogenicity Of Spleen Deficiency Mice

ObjectiveIn order to observe the response of spleen deficiency mice to intravenous infection of C.albicans.MethodsThe mice were fed with senna leaf decoction for seven days until the mice appeared some symptoms, such as diarrhea, bad appetite, emaciation and inactivity. Then the mice were injected C.albicans intravenously. The survival days of mice were observed for three weeks and the amount of live C.albicans in kidneys was calculated. The carbon particle clearance test and serum concentration of hemolysin were determined.ResultsThe results suggest that C.albicans can suppress the immune function of the normal mice significantly. The phagocytosis of macrophages and the production of antibodies fell obviously. The survival days of senna-treated mice were sharply shorted after the infection of C.albicans and the amount of C.albicans in kidneys was increased. In contrast, the survival days of the normal mice were not different after the infection of C.albicans.ConclusionIt means that C.albicans is lethal to spleen deficiency mice.