An Kidney Capsule Treatment Of Refractory Nephrotic Syndrome Phlegm And Permit Experimental Studies

Objective: An shen capsule (ASC) is based on long-term and good effect for refractory nephropathy syndrome (RNS), which is an experience compound prescri--ption. It has the action of eliminating phlegm, softening hard masses and removing blood stasis. To observe the curative effect of ASC on glomerulonephritis rats, asse--ss and explore its therapeutic efficacy and potential mechanism for RNS.Methods: Membranous nephropathy (MN) rats were produced by cationized bovine serum albumin (C-BSA). After one-week preimmunization, C-BSA had been injected in rat's tail vein one time every other day for 3 weeks. Except the nor--mal group, the animals were divided into five groups randomly, including the mod--eled group, the high-dose, the middle-dose, the low-dose, the tripteryguim wilfordii polyglycosidium (TWP) group. They were measured the proteinuria of 24 hours, hematuria, total protein, albumin, cholesterol, triglyceride and renal pathology rese--arch.Results: (1) ASC can reduce proteinuria and hematuria of MN rats. There are differences among the groups (P<0.05). Especially, the middle-dose group showed significantly (P<0.01). (2) ASC could in- increase albumin and decrease cholesterol and triglyceride. (3) It showed that ASC and TWP could relieve pathology changes of kidney, which are glomerulus's tumefaction, basement membrane's thickening, foot process's confluence and glomerulus's sclerosis.Conclusion: ASC has effect on RNS as good as TWP. It exerts the effect poss-ibly by regulating abnormal situation of glomerulus's filter membrane in MN rats.