| HeDan-capsule is taken orally to cure acute cholecystitisa and chronic cholecystitisa by acute outbreak. According to clinic efficacy, evaluating pharmacodynamics by using following experiments, for example using two kinds of experimental animal's gallbladder matrix(making coney's gallbladder channel infected by coliform and making Cavia cobaya cholecystitis by lincomycin),and cholagogue(the method of intubating big rat's bile duct and weighing albino rat gallbladder) antibacterial antifebrile antiinflammation abirritation etc. The results suggesting: (l)100mg/kg 200mg/Kg 400mg/Kg feeding coney by lavaging stomach, successive 7 days, the drug can ameliorat and cure coney its gallbladder channel infected by lincomycin; lowering temperature of infected pyretic animals, lowering the quantity of outer white blood cell which is enhanced by antiinfecton. Bacteria culturing and pathological section of tissue testing, after given drug, the inflammation of gallbladder can be reduced, the dosage of 400mg/Kg is the most obvious; (2) It can obviously reduce the Cavia cobaya cholecystitis aroused by lincomycin; (3) it can enhance the amount of draining bile by unit time, adding to bile secretion in a hour; (4) it has some antifebrile antiinflammation abirritation;(5)it has weak function of inhibiting outer bacteria.HeDan-capsule apparent pharmacokinetics research, making the target of cholagogue experiment(weighing albino rat gallbladder),doing pharmacology effect's experiment, The bile secretion of albino rat is one of adding numerical value, in order to eliminating the effect of test result by original bile in gallbladder, we improve the method based on original pharmacological effect, using the plan of given drug twice, its apparent pharmacokinetics process of storing in body accord to one unit matrix, apparent pharmacokinetics parameter: A: 179.326965mg/kg Ke: 0.014179 min-1, Ka: 0.057639 min-1, Lag time: 17.236338min, t1/2(Ka): 12.025690min, t1/2(Ke): 48.885319min, T(peak): 49.505959min, C(max): 85.566872mg/kg, AUC: 9536.108400(mg/kg)*min, CL/F(s): 0.010486mg/kg/min/(mg/kg), V/F(c): 0.739574(mg/kg)/(mg/kg)... |
