Lysophosphatidic Acid Testing Clinical Study In Acute Cerebral Thrombosis

Objective To study the level of plasma lysophosphatidic acid(LPA) in patients with acute cerebral thrombosis and to explore the mechanism of the stroke in progression . Methods 75 patients with acute cerebral thrombosis were one group,50 healthy persons served as control ; 75 patients were divided into two groups by the level of sugar : group hyperglycemia and group normal glucose; 75 patients were divided into two groups by the location of the cerebral infarction: group cortical branch of cerebral arteries infarction and group central branch infarction. 75 patients were divided into two groups by the symptoms and signs: group stroke in progression and group completed stroke,50 healthy persons served as control . LPA was extracted from plasma of patients and control. Results Plasma LPA levels of acute cerebral thrombosis were 8.4091±2.36163μmol/L, significantly higher than that in control group (3.0508±1.17242μmol/L) , P<0.0001;Plasma LPA levels of group hyperglycemia were10.0218±2.52138μmol/L,significantly higher than that in group normal glucose (7.4483±1.64755μmol/L) , P<0.0001;Plasma LPA levels of group cortical branch of cerebral arteries infarction were were10.0408 ±2.31677μmol/L, significantly higher than that in group central branch infarction(7.6412±1.97633μmol/L) , P<0.0001; Plasma LPA levels of group stroke in progression were 10.0292±2.12845μmol/L, significantly higher than that in group completed stroke (6.6539±0.88307μmol/L) and that in control group (3.0508±1.17242μmol/L),by analysis of variance P<0.0001. Conclusion As a molecular marker released by activated platelet in vivo , the level of plasma lysophosphatidic acid(LPA) in patients with acute cerebral thrombosis were significantly higher than that in control group; the level of plasma LPA in patients with hyperglycemia and cortical branch of cerebral arteries infarction significantly higher than that in the opposite;it suppose that the mechanisms of the stroke in progression may mainly be thrombosis and LPA as a molecular marker can reflect the situation of the activated platelet and the development of thrombosis, Plasma LPA may be valuable for predicting the development of acute cerebral thrombosis and guiding the treatment .