Study On The Correlation Among Lysophosphatidic Acid, Oxidized Lowdensity Lipoprotein, Subtypes Of Cerebral Infarction And The Carotidarteries Plaque Of Cerebral Infarction

Objective The study aims at exploring the correlation among lysophosphatidic acid(LPA),oxidized lowdensity lipoprotein(ox-LDL), subtypes of cerebral infarction(CI) and the carotidarteries plaque of cerebral infarction by observed the different levels of the LPA and ox-LDL in patients of CI.Therefore, Whether it is beneficial for ischemic stroke and the extent of atherosclerosis and plaque stability assessment, provides the basis for the anemic cerebrovascular disease patient early time prevention and the treatment.Methods we choose 123 patients who were diagnosed as CI within 3 days after the attack. All the patients who were divided into 3 groups:According to the number of incidence of CI, were divided into once and once more CI groups; Based on the clinical progress of CI, the patients were divided into progressive and non-progressive CI groups; According to neurological impairment score standards are divided into light, medium and severe CI groups; According to carotid artery ultrasound examination were divided into non-plaque group, hard plaque group, soft plaque group. At the same time 50 patients who without cerebrovascular disease were selected as control group. All of the subjects were using an improved method of quantitative determination of inorganic phosphorus LPA and solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) determination of ox-LDL. and carried out carotid artery ultrasound examination and determination of risk factors for stroke, such as blood pressure, blood glucose, blood lipids, blood viscosity, liver and kidney function and blood coagulation four other laboratory tests, All data are used SPSS13.0 software for analysis.Results 1. The levels of LPA and ox-LDL in the patients of the CI group are significantly higher than those in the control group(P<0.05), The detection rates of overall plaques and soft plaques of the CI group are significantly higher than those of the control group (P<0.05). 2.The levels of LPA and ox-LDL and the overall detection rate of plaques in the patients of the once CI group are significantly higher than those in the once more CI group(P<0.05), and the two groups hard plaque and soft plaque detection rate showed no statistical difference(P>0.05).3. The levels of LPA and ox-LDL and the detection rates of overall plaques and soft plaques of the progressive CI group are significantly higher than those of the non-progressive CI group(P<0.05).4. The levels of LPA in the patients of the medium and severe CI group are significantly higher than those in the light CI group(P<0.05); the level of ox-LDL in the patients of the severe CI group are significantly higher than those in the light CI group(P<0.05); the detection rates of overall plaques and soft plaques of the medium and severe CI group are significantly higher than those in the light CI group(P<0.05).5. The levels of LPA and ox-LDL in the patients of the soft plaques group are significantly higher than those in the non-plaque group and hard plaques group(P<0.05).Conclusion 1. The levels of LPA and ox-LDL in the patients of CI were significantly higher. ,the rate of discovering carotidarteries plaque increased.2. The levels of LPA and ox-LDL were correlated with subtypes of CI,there are have the higher levels of LPA and ox-LDL in the patients of the once more, progressive and severe CI.3. The the more levels of LPA and ox-LDL of CI patients,the more rate of discovering carotidarteries plaque, main plaques constitution were soft plaques.