Radix curcurnae is one of traditional Chinese medicine, widely used in clinic.In traditional effects,it has the function of activating blood and qi circulation, alleviating pain, alleviating depression, clearing away heart-fire, promoting the function of the gallbladder to alleviate jaundice and cooling blood.According to Chinese pharmacopoeia 2000 edition , there are four botanic origin of Radix curcumae: Curcuma longa L.(Huangsi yujin) , C.wenyujin Y. H. Chen et C. Ling, C. kwangsiensis S. G Lee et C. F. Liang(Gui yujin), C. phaeocaulis Val.(Lvsi yujin). In addition, there are aslo two local species : Curcuma longa L.cv.chuanyuji(Huangbaisi yujin), Curcuma phaeocaulis Val. cv. Sichuannensis(Baisi yujin).The reasearch focused on the difference of all these 6 varieties including the chemical element and pharmacological effect intensity. We estimated the effects of Radix curcumae on 6 parameters(TC, TG, HDL of blood serum, blood clotting time, low shear rate and high shear rate of the whole blood viscosity) and the curcumin content of them together,the results showed that:1.The curcumin content in 6 varieties of Radix curcumae are significantly different,except for Huangsi yujin and Huangbaisi yujin,there are little curcumin in the other four varieties.The ratio of the content of curcumin is,Huangsi yujin: Huangbaisi yujin: Lvsi yujin: Baisi yujin: Gui yujin: Wen jujin=100 : 63.8 : 0.69 : 0.45 : 0.41 : 0.36.2.The pharmacological effect intensity of these 6 samples are also significantly different. From high to low,the total scores of the 6 pharmacological parameters is,Huangsi yujin:Lvsi yujin:Huangbaisi yujin:Wen yujin:Gui yujin:Baisi yujin =440.6 : 435.3 : 370.9 : 352.9 : 255.5 : 247.2.3.Compare with pure curcumin, we proved that the pharmacological effect of Huangsi yujin was mainly based on the effects of curcumin in it, the contribution accounted for 94.72%,so curcumin as the active factor of the pharmacological effect... |