| Tibetan medicine Sangdang was recorded of its effect of removing dampness in 《JINGZHUBENCAO》 .It could relieve the symptoms such as red, swollen , pain of joint . Sangdang was choosed to treat hyperuricaemia and gouty-arthritis from a great deal of Tibetan proved recipes for the first time under the guidance of TCM and Tibetan medicine theory.This research concluded following experiments: abirritation; anti-inflammation; hypouricuria; anti-gout. The results showed that it could remarkably decrease the twist-reaction stimulated by acetic acid; enhance the pain threshold induced by heat irritation; restrain the inflammation induced by egg white, dimethylbenzen and tampon. It could reduce the uric acid of animal model; depress xanthenes oxidation enzyme(XOD).It could markedly relieve the swollen foot of animal model of gouty arthritis. It could reduce the content of 5-HT and DA in blood serum and the content of TNF-α, IL-1β, IL-6 in joint; increase the content of 5-HT and DA in nerve centre.Conclusion: Sangdang had good effect on gouty arthritis and hyperuricaemia. Its treatment of hyperuricaemia had something to do with depressing XOD. The mechanism of anti-gout was adjusting the content of 5-HT and DA, and decreasing the content of TNF-α, IL-1β, DL-6 in joint. |
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