The Pharmacy,Pharmacodynamics And Clinical Studies Of TongFengNing On Treating Gouty Arthritis

1. Backgrounds: The prophase studies showed that the drug granules hadgood effect on anti-inflammatory, antioncotic, and analgesic action and the good effect of promoting blood circulation. It is significant to develop the patent medicine that is effective on treating gouty arthritis.2. Objectives :The investigation is to regulate the preparationtechnology process and consummate systemic clinical effect observation in the prophase. The acute toxicity experiment, general pharmacodynamics and main pharmacodynamics experiments also have been done. The study that is regulated by report for the third new medicine of Chinese traditional medicine, including the pharmacy, pharmacodynamics and toxicology experiment, have mostly been finished to lay down the foundations to report for the third new medicine of Chinese traditional medicine.3. Materials and methods:(1)The pertinent literature about hyperuricemia and gouty arthritis were surveyed by multifold reviewing systems, to learn the study progresses of Chinese traditional medicine and western medicine.(2)The study of medicinal material pharmacy that was regulated by theprescription was made. The sequence of specification technic flow has been formulated according to the prescription's characteristic and convenience for intaking, after many trials and the innovation of the preparation technology.(3) It has been proceeded of acute toxicology test and pharmacodynamics investigation of anti-inflammatory, antioncotic, analgesia and promoting blood circulation of the drug granules of TongFengNing.(4)The major pharmacodynamics investigations: to comparatively observe the effect of TongFengNing on blood uric acid metabolism through experimental hyperuricemia mice model; to comparatively observe the effect of TongFengNing on arthrositis induced by specific sodium urate through the rat arthritis model induced by sodium urate; to comparatively observe the influence of TongFengNing to the generation and excretion of uric acid and gouty arthritis through gouty model of hen.(5)To proceed clinical effect observation of Drug granules of TongFengNing to acute gouty arthritis .vs. Xinhuangpian.(6)To proceed clinical effect observation of Drug granules of TongFengNing to chronic gouty arthritis .vs. probenecid4.Results:(1) Indicated by the literature research by far showed that the diagnosis and treatment and research to gouty arthritis had not been paid much attention in clinical, and the systemic researches to traditional Chinese medicine was deficiency, and there is not generally accepted animal model of hyperuricemia and gouty arthritis, and there was lack of ideal patent medicine of TCM.(2) It has been confirmed that this prescription' s chemical preparation is drug granules, and it has formulated a sequence of specification technic flow such as extraction, concentration and molding. The trial of this preparation has been already produced a lot agent to put into experimental and clinical research.(3)Indicated by the acute toxicity trial to this new preparation: it issafe to take the drug granules of TongFengNing 36g per day (about 0.8g/kg).(4)Indicated by the general pharmacodynamics: the drug granules of TongFengNing of high and low doses both have preferable analgesia, promoting blood circulation, antioncotic and analgesic action. And there is not significant difference between the high dose group and soraedon, Ligustrazine, eye-cort.(5)Indicated by the major pharmacodynamics researches: the drug granules of TongFengNing can significantly decrease the blood uric acid of the mice hyperuricemia model induced by hypoxanthine injection; it is outstandingly to inhibit the swelling and pain of joint and inflammatory reaction of the rat arthritis model induced by sodium urate crystal; it can inhibit the production of blood uric acid of the gout disease chicken model, promote the excretion of uric acid, and relieve the joint inflammatory reaction.(6)Indicated by the clinical effect observation to acute gouty arthritis:...