Peony Root Of Anti-tumor Activity Of Pairs Of Glycosides Injection

Antitumor actived, immunological enhancing effects and leukogenic effects of Baishao shuanggan injection were investigated in this paper.Antitumor activites were assayed by using mice carring transplanted sarcoma S₁₈₀ and MethA as an animal model. Baishao shuanggan injection at dosage of 12.5, 6.25 , 3.125mg·kg^-1 has obvious inhibit effect for mice bearing S₁₈₀ tumor, the inhibitition rate of 55.5%, 47.2%, 39.6% and obvious prolonged the survival time of mice bearing MethA tumor, the life prolong rate of 78.4%, 44.6%, 31.7%. At the dose as above has obvious immunomodulating effect for mice bearing S₁₈₀ tumor. The phagocytosis function of celiac macrophage could be recovered, the activity of NO from the spleen cells was improved, the production of TNF-α from the supernatant of peritoneal macrophages and IFN-γ from spleen cells was enhanced , the cytotoxicity activities of NK from the spleen cells was enhanced, furthermore the T lymphocytes proliferation could be increased.Immunological enhancing effects were studied by using immunosuppressed mice as an animal model. Baishao shuanggan injection at dosage of 12.5,6.25,3.125mg·kg^-1 has obvious enhanced immunological for immunosuppressed mice. The phagocytosis function of celiac macrophage could be recovered, the cytotoxicity activities of NK from the spleen cells was enhanced, the white blood cell count of peripheral blood was enhanced, and the coefficients of spleen was improved.Leukogenic effects were studied on mice or rabbit leukopenia models. Baishao shuanggan injection at dosage of 12.5, 6.25, 3.125mg·kg^-1 could obviously increase the counts of white blood cell, platelet, bone morrow karyocyte and the content of hemoglobin, could come into being normal about the classify of peripheral blood and bone marrow, could ease arrest of bone marrow , furthermore could improve the coefficients of spleen on mice of raying by X-ray and inject by cyclophosphamide. Baishao shuanggan injection at dosage of 4.64, 2.32, 1.16 mg·kg^-1 could obviously increase the counts of white blood cell, platelet, bone morrow karyocyte and the content...