Dna Model Molecules And Epinephrine Interaction

DNA is the basic genetic material in biology, the carrier of genetic information and the material base of gene expression, which plays decisive function to the biological evolution and decides the direction of biological development. Meanwhile the basic unit which constitutes nucleic acid is the alkali base- the cytosine, thymine, uracil, adenine and guanine. They are all heterocyclic compounds including the nitrogen atom which is in the same conjugate-system and are vital to the biological system. Adrenaline is an important neurotransmitter of mammals and human beings, which controls both the nervous system to carry out a series of biological reactions and nerve chemical processes. Adrenaline is also a kind of biological molecules. The research of intermolecular mutual function of biology is the foundation of understding the biological system's special function and distinguishing the mechanism. To study the interaction between alkali base and adrenaline can propel the development of biology, pharmaceutical chemistry and physical chemistry, etc. In this paper we used electrical chemistry method to study the CV of adrenaline with cytosine, thymine and uracil, meanwhile the quantum chemistry method was used to investigate the interaction of hydrogen bond between adrenaline and three alkali bases.Cyclic voltammetry was used to study the effect of cytosine, thymine and uracil on the cyclic voltammetric properties of adrenaline in the KRPB buffer solution. The results indicated that three alkali bases had stabilization on adrenaline, so that the ability of oxidation of adrenaline decreased, which altered the cyclic voltammetric properties of adrenaline. Because the cytosine's solubility in three alkali bases is comparatively great, we studied the cytosine on the cyclic voltammetric properties of electron transfer of adrenaline in different medium. The results showed that the cytosine had different stabilization in different system to adrenalin, namely the different constituents of system had certain influence to the interaction bewteen alkali bases and adrenaline.The structure including carbonyl is the main existence of cytosine, thymine and uracil, we optimized their configurations. The hydrogen bonding complexes could be formed between adrenaline and them. The quantum studies were carried out in this thesis. The geometries of adrenaline and the stable complexes were respectively optimized to obtain structural parameters and binding energies. Meanwhile we optimized the hydrogen bonding complexes between cytosine whose structure includied hydroxy and protonation's adrenaline. Structural parameters and binding energies were also obtained. The calculation results could be better used to explain some experimental phenomena.