| Objective:To investigate the clinical effect and anti-influence of western medicine of the basic prescription on treatment of active lupus nephritis,try to find out the mechanism of Huo Xue Jie Du prescriptionthrough clinical experiment.Methods:40 patients with active lupus nephritis were selected and randomly divided into two groups:the united Chinese and western medicine treatment group(A)and western medicine control group(B),20 patients for each group.Group B were given criterion prednisone orally taking and cyclophamide impact therapy in injection.Group A were given Huo Xue Jie Du prescription with dialectically adding other herbs on the base of group B.We observed on the/their symptoms and signs pre-treatment and post-treatment.Blood-routine,urine-routine,stool-routine+OB,BS, ALB,AST,BUN,Scr,C3,ESR,ANA,anti-ds-DNA,24hupq,active degree of lupus were measured to evaluate the effect of the united Chinese and western medicine therapy.Result:Result of the study could be summarized as:1.Group A total effective rates were 90.00%;while group B was 50.00%;the total therapeutic effect of group A was better than that of group B(P＜0.05)2.Group A could improve the patients' clinical symptoms and signs,the effects was better than group B(P＜0.05 or 0.01)3.Group A have better effect than group B in anti-side-effect of prednisone and cyclophamide(CTX)such as Cushing syndrome,excitement,insomnia or descent of white blood cell(WBC)(P＜0.05)4.Compared with group B,group A has differential effect in decreasing urine protein(P＜0.05) 5.The time of controlling the clinical symptoms,signs,experimental index has remarkable less in group A than that of group B(P＜0.01 or＜0.05)Conclusion:Group A were better than group B in symptoms and signs of the patients,western medicine anti-influence and experiment index after the treatment.Therefore,the united treatment could markedly keep long-relieve in the patient of lupus nephritis. |
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