Blood Circulation Town Miscellaneous Reversal Of Hypertensive Left Ventricular Hypertrophy Theory And Mechanism In China

BackgroundLeft Ventricular Hypertrophy (LVH)is one of the most commoncomplications of hypertension.It is not only the occurrence anddevelopment of the relevant factors and hemodynamic, neurological,endocrine, and other factors also play an important role. In theFramingham Heart Study, a large number of long-term follow-up resultssuggest that hypertensive patients with left ventricular hypertrophyin sudden death, the risk of myocardial infarction increasedsignificantly, Devereux years of follow-up showed that the survival ratein patients with left ventricular hypertrophy associated with asignificant drop.LVH is an independent risk factor of cardiovasculardiseases now.It is important to discover mechanisms of LVH and to findpreventive measures,which have significance in the field of boththeoretic studies and clinical practice.Morerencently,rennin-angiotensin system (RAS) activation has beenunderstood to be a major inducer of cardiac tissue hypertrophy.It hasbeen demonstrated that the local cardiac tissue hypertrophy.It has beendemonstrated that the local cardiac angiotensinⅡ(AngⅡ) is a potentgrowth factor in LVH,which can bbe blocked by AT1 receptor antagonists.There is no LVH of hypertension in Chinese medicine,but the basicknowledges of a series of changes of LVH of hypertension and body ofhuman health are balance and imbalance of yin and yang in human bodybased on basic theory of Chinese medicine.The body of human health isbased on the yin and yang interdependence for each other,such as yinwanes,yang waxes,and vice versa.A series of complications ofhypertension result from imbalance of yin and yang,while LVH ofhypertension is formed new relative balance under new circumstances.Therelative balance is the compensated results of preceding imbalance ofyin and yang.The pathologic basis of LVH os blood stasis,qi deficiencyand yin insufficiency of liver and kedney.The treatments of drugs arepromoting blood circulation,reinforcing qi,replenishingkidney,tonifying liver and nourishing yin.Such treatments get someclinic improvement of patients.Objectives By summing up the past 15 years of literature on the angiotensinⅡinduced myocardial hypertrophy and related signaling pathway,themechanism,about method of invigorating the circulation of blood andcalming heart to kickback hypertension LVH,could be researched.Andthrough pre-experimental of the feasibility study,pre-conditions toprepare for further study.Methods"Left ventricular hypertrophy","signal transduction"and"myocardial cells"as literature Review keywords, the relevantliteratures are selected from CNKI database."Left VentricularHypertrophy","Signal transduction pathway"for the first Key wordsand"AngiotensinⅡ"as the second search Pubmed to find relatedliterature. Summing up causes of disease, pathogenesis, syndrome typeand Treatment, TCM theory on the method of invigorating the circulationof blood and calming heart medication hypertension LVH is perspective.Western medicine from the perspective of signal transduction startsumming up signaling protein associated with LVH and to look for thoseknown existing and more close to LVH but research few, as well as thebreakthrough of experimental study.The first step of experimental research is adding angiotensinⅡto the original cultured myocardial cells and giving western or chinesemedicine to intervention.Then Second is to detect the difference intotal protein content of blank group,model group,the WM group, Chinesemedicine groups by Coomassie Brilliant Comparison.At last to select theoptimal drug concentration points.Conclusions(1) The formation of hypertension left ventricular hypertrophy isclosely related neuroendocrine factors.The stimulation signals, mainlythrough PKC and MAPK signaling pathway , increase protein synthesis ,cell volume and mesenchymal collagen synthesis which have LVH.(2) Hypertension and hypertension left ventricular hypertrophy TCMDifferential Treatment existence identity, and blood stasis isthroughout the whole course of the pathological mechanism.(3) Invigorating the circulation of blood Chinese drug danshen,Chuanxiong, and other components and can inhibit AngⅡcaused myocardialhypertrophy. (4) AngⅡon cultured neonatal rat cardiomyocytes cells significantly promote the role of mast.(5) High concentrations of Jiangya Tongmai Decoction have myocardial cytotoxicity.(6) Jiangya Tongmai Decoction can inhibit the AngⅡ-induced myocardial hypertrophy, and its principles may inhibit PKC and MAPK signaling protein expression.