PTEN, And Cd44v6 And P27 Expression In Gastric Carcinoma And The Correlation Study And Its Clinical Significance

Objective:Discusses.PTEN,CD44v6.and.P27.in.stomach.cancer's.expression,relevant.and.with.the.stomach.cancer.clinical.pathology.characteristic.and.the.lymph.node.shift.relations,thus.for.stomach.cancer's.early.diagnosis,the.early.treatment.and.the.prognosis.appraisal.provides.the.reliable.theory.basis.Methods:Collects.30.example.normal.stomach.organization,63.example.primary.stomach.cancer.organization.and.nearby.the.corresponding.cancer.organizes,makes.the.frozen.section.Uses.the.immunity.histochemistry.SP.method,examines.PTEN,p27,the.CD44v6.protein.in.expression.situation,the.union.clinical.material.carries.on.the.statistical.analysis(p<0.05)Results:1.The.PTEN.protein.locates.in.the.cytoblastema,assumes.the.masculine.gender.in.the.normal.stomach.organization.to.express.completely,expresses.the.level.in.the.cancer.peritonsillar.tissue.to.be.higher.than.the.cancer.to.organize,the.difference.has.the.significance.(P<0.05)2.The CD44v6 protein locates in the cell membrane and near membrane cytoblastema,in examines in the normal stomach organization, the cancer peritonsillar tissue assumes thenegative to express, is lower than assumes the masculine expression the stomach cancerorganization, the difference has the significance (p<0.05).3.the p27 protein organizes nearby the stomach cancer and the cancer the expressionto locate in the cell nucleus, assumes the masculine gender completely in the normalstomach organization. In the stomach cancer the p27 high expression rate is lower thannearby the cancer to organize, and both are lower than the normal gastric mucosa, thedifference has the significance (p<0.05).4.The stomach cancer organizes PTEN, CD44v6 and the p27 protein expression withpatient's sex, the age, the tumor spot and the size does not have the relevance, splits up thedegree, the infiltration depth, the lymph node shift and TNM with the tumor is by stagesrelated. The low differentiation, invades and the serosa level, has the lymph node to shift or TNM by stages the high stomach cancer organization, PTEN, the p27 masculine genderexpression rate remarkable drop; But the CD44v6 masculine gender expression rateobviously elevates, the difference has the significance (p<0.05).5.In the stomach cancer the PTEN expression and the p27 expression present isrelated; Assumes the inverse correlation with the CD44v6 expression; the p27 expressionand the CD44v6 expression assume the inverse correlation (p<0.05).Conclusion:PTEN, CD44v6 and the p27 gene and stomach cancer's occurrence, thedevelopment concern. And with stomach cancer's split up degree, shift, infiltration depthand clinical by stages related, prompts may shifts the potential as the judgment stomachcancer time progress and the forecast stomach cancer the auxiliary biology target.thus forstomach cancer's early diagnosis, the early treatment and the prognosis appraisal providesthe reliable theory basis.