Studies On Chemical Constituents Of Lobelia

Lobelia is Campanula half lotus plants Lobelia sessilifolia Lamb with the whole grass roots.Produced in northwest China's Yunnan Province,northern Guangxi,Zhejiang,Taiwan, Shandong,Hebei,Liaoning,Jilin and Heilongiiang.According to the "Chinese herbal medicine" there are records Lobelia cough expectorant,diuretic swelling,Qingrejiedu function.This paper chromatography technology and the use of modern methods of separation of osteoclasts wind ethanol extract of the system separation,isolated from the four compounds,and through UV spectrum,mass spectrometry and nuclear magnetic resonance spectroscopy(¹H-NMR, ¹³C-NMR,HMQC,HMBC) spectroscopy,and other modern methods and techniques to identify their differences to the structure of Lobelia-alkali,alcohol doomed to a mountain base,1-[2-(2-hydroxy-C)-2-piperidinyl]-2-butanone, glucose.One-[2-(2-hydroxy-propyl)-2-piperidinyl]-2-Butanone is a new compound,and the remaining two alkaloids for the first time from this plant were isolated.Multi-use electrospray ionization tandem mass spectrometry(ESI-MSn) Lobelia total alkaloids in a qualitative analysis,based mainly on the three isolated alkaloids are ion electrospray mass spectrometry scan showed the conditions MS characteristics,be Lobelia alkaloid compounds in the possible cracking of electrospray ionization mass spectrometry, initially set Lobelia contains alkaloids structure of the six,four of which may be new alkaloids, awaiting further Spectral evidence for corroboration.Through studies,the establishment of an effective,rapid and sensitive Electrospray Tandem Mass Spectrometry analysis for future research in this genus alkaloids active ingredients provide rapid analysis,a powerful means of identification.Carring on GC-MS analysis to Lobelia sessilifolia Lamb authenticate 18 compounds.