2. Anti-fatigue Treatment Of Liver Depression And Heart And Spleen Deficiency Type Sub-health Clinical Study Of Chronic Fatigue

Sub-health is a state between health and disease.People who got this state would feel uncomfortable,but they are not get any disease when be checked by the medical equipment.Fatigue is the decrease in capability of work,which is caused by over-work includeing brainwork and physical work,and it is the first facter of sub-health.According to the material,5%～20%of common people have the experiences of continue fatigued.There are 5%～20%patients' main suits are fatigued.And fatigue is the most important accompany symptom of 5%～20% patients.In amrican there are 24%adults have the experiences of tired lasted for 2 weeks or longer,59%～64%of them do not have any disease.At present,in china, there has less discussion about the causes and pathogenesis in chronic fatigue of sub-health,moreover the diagnosing standards and the effective treatments which has acknowledged by the great majority experts are not formed.So it was the most urgently problem we should deal with at present.Objective:Discuss the cause of disease and pathogenesis of chronic fatigue of sub-health.In this stage we evaluate the effectiveness and safety of anti-fatigue No.2 when it used in patients who has chronic fatigue of sub-health.Establish foundation to.developing traditional chinese medicine patent prescription which has better effectiveness and in accordance with clinical practice.Method:Useing the consolation contraposition method which is block randomization single blind single modelling,randomly divided the 40 outpatients into treated group and contrapositional group what the treated group has 20 patients and the contrapositional group has 20 patients.This two groups are separately gave the anti-fatigue No.2 exempted trad grain drug and consolation,which have obeserved three weeks.Results:1.Compared the informe cured situation between the treated group and the contrapositional group what the treated group has 20 patients and the contrapositional group has 20 patients in the 40 outpatients who has chronic fatigue of sub-health,the results indicated that age,weight,height,TCM symptom aggregated score,each symptom of TCM,FSAS aggregated score has not statistical difference,sex has statistical difference.2.Compared the third week situation between the treated group and the contrapositional group what the treated group has 20 patients and the contrapositional group has 20 patients in the 40 outpatients who has chronic fatigue of sub-health,the results indicated that the aggregateed scores of TCM symptom has statistical difference;in the FSAS score,total score of fatigue,mental fatigue,physical fatigue,result of fatigue,the reaction of body to resting has statistical difference,but the situatedness of fatigue does not has statistical difference;in each symptom of TCM,hypodynamia,emotion depression,impatience and irascibility,spirit fatigue,stool abnormity has statistical difference,other symptoms do not have statistical difference.3 Compared the third week cured situation between the treated group and the contrapositional group,the result indicated cured effectment,aggregate score of before cure and after cure,TCM mainly symptom has statistical difference.4.The 40 outpatients do not have adverse reaction.In the 40 outpatients,2 outpatients which was in the cured group have liver function and kidney function,5 outpatients which was in the contrapositional group have liver function and kidney function,before and after cured.The 7 outpatients do not have liver function and kidney function harm.Conclusion:1.The main pathogenesis of chronic fatigue of sub-health are liver depression.spleen exhausted,heart deprived.The location of disease include live,spleen and heart.2.The chronic fatigue of sub-health is a clinical condition which caused by over pressure and depressioned feeling.It involve in many facts inclding social and psychology etc.It has many clinical shows.The common symptom are hypodynamia,emotion depression,impatience and irascibility,spirit fatigue,loss of memory,distending pain of chest and hypochondriu,mmamma,lower abdomen,stool abnormity,parahypnosis,anorexia,abdominal distention,dizziness, palpitation,which was ordered according to priority.3.The research results find that the treat effectment of anti-fatigue No.2 group was better than the contrapositional group(P＜0.0002)(the effective rate of the treated group is 84.21%and(the effective rate of the contrapositional group is 26.32%).It can mainly improve clinical symptom of chronic fatigue of sub-health.The main TCM symptom effective rate of the treated group and the contrapositional group are 84.21%and 26.32%.It indicates that the main TCM symptom effective rate of the treated group is better than the contrapositional group(P＜0.0001).The comparison results of each curative effect what are TCM symptom aggregated score,each symptom of TCM,FSAS aggregated score after treatment indicated that the treated group is better than the contrapositional group in improveing patients's symptom of TCM and FSAS aggregated score,what the symptoms are hypodynamia,emotion depression, impatience and irascibility,spirit fatigue,stool abnormity.The statistics outcome of adverse event(chart5-1)indicated that anti-fatigue No.2 have fine safty.