Hifu Treatment For Vulvar Squamous Cell Hyperplasia Of Bfgf In, Fgfr-1 Expression

Vulvar squamous cell hyperplasia is one kind of pathologies of vulvar nonneoplastic epithelial disorders.It's a disease which is composed mostly of benign squamous cell hyperplasia in vulva.And the major clinical menifesitations are vulvar hypopigmentation,pruritus,and epidermis thickening.It's uncausal and resistant,which can affect women's quality of life.There are many kinds of therapies,but few are effective.In recent years high indensity focused ultrasound therapy of this disease has made good effect.The purpose of this study was to investigate the feasibility and efficacy of focused ultrasound treatment of vulvar squamous cell hyperplasia in human.And found the possible mechanism for clinical treatment.Objective:To explore the expression of bFGF and FGFR-1 before and after the therapy of HIFU in vulvar squamous cell hyperplasia,and found out the feasibility mechanism.Method:bFGF and FGFR-1 were positively expressed in the vulvar of 30 patients before and after HIFU treatment by the immunohistochemistry method,which were used to evaluate the possible mechanism.Results:The expression of FGFR-1 in lesions of SH(4/30,13.3%) are lower than that in normal skin(13/30,43.3%)(P＜0.05).The expression of bFGF in lesions of SH(5/30,16.7%) are lower than that in normal skin(14/30,46.7%)(P＜0.05).One month after the treatment,both the expression of bFGF(26/30,86.7%) and FGFR-1(24/30,80%) increased significantly,(P＜0.01).There is no differences between normal vulva of the patients and vulva of normal women,(P＞0.05).Conclutions:1.HIFU can prove the expression of bFGF and FGFR-1,which may be one of the most important mechanisms of its therapy.2.The decreasing of the expression of bFGF and FGFR-1 may be related to the onset of vulvar squamous cell hyperplasia.