Correlation Of Traditional Chinese Medicine Syndrome Of Chronic Heart Failure And Ca125

Objective:To explore the patients with Chronic heart failure syndromes transformation of Chinese traditional medicine and echocardiographic parameters of cardiac function, NYHA classification and serum CA125 concentration. A statistical analysis of all indexs of 80 cases with chronic heart failure patients and 20 cases heart function parameters of non-heart failure patients, CA125 levels, etc.was done.Methods:To meet the diagnosis of chronic heart failure patients with New York Heart Association (NYHA) classification, the traditional Chinese medicine(TCM)syndrome differentiation, the researches evaluated the patients with suspected heart failure by the standard of Framingham in the Dong Zhimen Hospital's cardiological Department of Beijing University of Chinese Medicine from January,2008 to December,2009. And selected the non-heart failure patients as normal contrastive groups who were in Dong Zhimen Hospital. The researches also measured all the elect patients by immunofluoresence CA125 concentration, and measured left ventricular end diastolic diameter (LVEDd) and ejection fraction (EF) for echocardiography with two patients. The result were dealt with SPSS13.0 statistical software, significance level 0.05.Results:The researches included 80 patients with chronic heart failure,18 cases of TCM qi deficiency,20 cases of yang deficiency,23 cases of blood stasis,19 cases of phlegm card. If we classificate all the patients with heart failure according to NYHA, there will be 8 patients of NYHA-I, 22 of NYHA-Ⅱ,27 of NYHA-Ⅲ,23 of NYHA-Ⅳ,20 of non-heart failure in contrastive groups. According to statistical analysis, chronic heart failure and non-heart failure patients are no significant difference in age, gender and so on, moreover, four syndromes of age and gender are no significant difference in the aspect of statistics. There are some statistic difference between chronic heart failure patients and the patients of non-heart failure in the parameters of heart function, and also have significant differences (p<0.01) in terms of serum CA125 levels. Chronic heart failure patients have statistical significance with the increase of NYHA, LVEDd, CA125, the EF value will decrease gradually. Four symptoms of Chinese medicine have difference in NYHA classification, EF value (P<0.05), but no difference in LVEDd (p>0.05). The cardiac function is gradually deteriorate from deficiency of vital energy to stagnation of blood, to phlegm and lack of vital energy through statistical analysis. According to the analysis of serum CA125, the four different symptoms in serum CA125 are difference, the highest is lack of vital energy, phlegm card is next, deficiency of vital energy is the lowest, and they also have statistical difference (P<0.05)Conclusions:Firstly, LVEDd of chronic heart failure patients is gradually increased with NYHA gradeⅠ-Ⅳlevel, while the EF value is subsequently decreased, both of which are important indicators reflecting the NYHA classification. Similarly, the serum CA125 concentration is also reflected in NYHA classification, and the serum CA125 levels will increase with the deteriorate of cardiac function and classificate of NYHA'sⅠ-Ⅳlevel. Secondly, Chronic heart failure syndrome's distributions and sub-types have certain regularity, deficiency of vital energy, stagnation of blood, phlegm and lack of vital energy are the basic symptoms. The development and distribution of Chinese medicine' s pathogenesis and symptom can be summarized as the transformation of deficiency of vital energy--stagnation of blood--phlegm--lack of vital energy, and to some extent reflects cardiac function and serum CA125 situation.