| Objective:Using "Guanxinping"which can supplement qi and nourish yin, promote blood flow and eliminate phlegm to treat coronary heart disease patients, various biochemical indicators and clinical manifestations changes could be compared before with after taking the preparation, evaluating the treatment of curing coronary heart diseases, and safety; And observing the levels of inflammatory markers before with after the treatment, such as Resistin, allergic c-reactive protein (CRP), interleukin hs-6 (IL-6), tumor necrosis factor (TNF); And indicators related the function of arteries, such as PWV(Pulse wave velocity),ABI (Ankle Brachial Index). In order to clear that how"Guanxinping"affects the levels of vascular inflammation factors in patients with coronary artery disease, and investigate the mechanism that how it affects indicators related the function of arteries in patients.Method:1.Collecting patients who diagnosed with coronary heart disease(excepting myocardial infarction) from March 2010 to January 2011 in Jiangsu TCM hospital Cardiovascular in-patient Department.The total number of experimental and control group is 40, each 20 cases, the former group take " Guanxinping " and western medicine standardized treatment, the latter group only take standardized treatment, the course lasts for eight weeks, observing clinical symptoms'changes before with after the treatment and record changes of Resistin, Hs-CRP, IL-6, TNF-α,PWV and ABI, monitoring the safety index (with blood,urine,kidney function and so on). Using enzyme-linked immunosorbent adsorption (ELISA) double antibody clip to detect plasma resistance element level. hs-CRP uses immunoturbidimetry(ITM) to analysis.IL-6, TNF-αmeasuring uses enzyme-linked immunosorbent double antibody clip to detect; Using Japan colin arteriosclerosis blood vessel function checks (PWV, ABI).2.Statistical analysis:Descriptive statistic analysis Qualitative index use percentage and Quantitative index use mean and standard deviation. In evaluating significance, the Chi-square analysis was used in Quantitative data and "t" analysis was used in evaluating qualitative data. Statistical analysis was done with SPSS software.Result:1.Two groups of patients'symptoms before with after treatment improve, and the experimental group (P<0.01), has statistically significant meaning; The control group (P< 0.05), with a statistical significance. And the improvement of TCM symptoms is much better, comparing with controls with a statistical significance (P< 0.05). It is sure that the two group can improve TCM clinical symptoms, and the effect of experimental group is better.2.The numerical values of IL-6 and TNF-αabout two sets of patients who take treatment are better than before treatment (P< 0.05), significant; But on the improvement extent of two vascular inflammation factors, experimental group has no obvious advantage than control group, no significant difference compared with the control group (P>0.05).The numerical values of serum resistance about two sets of patients before with after treatment both have no improvement, P>0.05, no statistical significance.3.The numerical values of PWV-L about two groups of patients who take treatment are better than before treatment (P< 0.05). But the improvement extent of experimental group compared to controls has no obvious difference, P> 0.05, no statistical significance, is said that the improvement extent of experimental group isn't better than controls, there isn't a positive result; The numerical values of PWV-R about he control group that after treatment comparing to before treatment were obviously improved (P< 0.05), but the vaules about patients who take treatment has not improved obviously comparing to before treatment (P> 0.05). The numerical values of ABI-L about the control group who take treatment improve obviously comparing to before (P< 0.05), and the values of ABI-R about control group and the values of ABI-L,ABI-R about experimental group who take treatment aren't better than before treatment (P>0.05).Conclusion:Guanxingping which have the effect of supplementing qi and nourishing yin, promoting blood flow and eliminate phlegm to treat coronary heart disease has positive curative effect and improve clinic TCM symptoms. the therapeutic mechanism is probablely that through affecting the levels of vascular inflammatory factor to delay the process of vascular inflammation, and get the aim of treatment. |
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