Clinical Value Of Blood-lipid And Lipoprotein Metabolism Changes And CEA, CA199 Detection In Gastric Cancer

Background and ObjectiveNumerous epidemiological studies have demonstrated that gastric carcinoma in China accounts for about 95% of stomach cancer, the death rate of which each year ranks secondly. Men's incidence and mortality rate of gastric carcinoma are higher than that of female, about 2:1. And the incidenceage is middle-aged, during 55 to 70 years as the high period.The best global gastric cancer clinical evidence shows that the main factors affecting the prognosis are the TNM stages, tumor location, histological types, biological behavior and treatments to gastric cancer and so on.5-year prognosis survival of gastric cancer is related to the staging. Early stage ones are almost asymptomatic, the diagnosis rate in (0～Ⅰstages) is low (about 10%) and most of them are in the middle and late periods, so the 5-year survival rate is low (about 7 to 34%).Tumor markers such as CEA, CA199 increase mainly in stomach and other gastrointestinal malignancies, and we also found that blood-lipid and lipoprotein metabolism in patients with cancer change to different degrees, Can the blood lipid levels in patients reflect the certain metabolismas aspects of tumor as CEA, CA199 do? We retrospectively study the levels of serum CEA, CA199 and lipid, lipoprotein in 158 gastric cancer patients, and discuss the clinical value of serum CEA, CA199, TG, TC, HDL, LDL levels in gastric cancer through analysising them by comparing to control group.Materials and methods1 study:Collecting 338 cases of the First Affiliated Hospital of Zhengzhou University during September 2006 to July 2010, which are divided into three groups:①158 cases are included in gastric cancer group, including 62 cases treated by chemotherapy directly without surgical operation and 96 cases firstly operated then treated by adjuvant chemotherapy.②100 cases are included in normal control group.③80 cases are included in benign disease group (gastritis and gastric ulcer).2 Samples collection and blood lipids, lipoproteins, CEA, CA199 detections: collecting two tubes's blood in morning, measuring the levels of serum TG, TC by enzyme, serum HDL, LDL levels by chemical precipitation (PEG method), and serum CEA, CA199 levels by radioimmunoassay, and completing quantitative analysis.3 Statistical analysis:Analysising the levels of blood lipids, lipoproteins, CEA, and CA199 among gastric cancer group, gastric benign disease group and control group; Analysising levels of each index cases between gastric cancer preoperative group and postoperative group; Analysising the relationship between the levels of the indicators and the clinicopathological stages in gastric cancer group; Analysising the levels of the indicators in gastric cancer group according to efficacy groups; Analysising the correlations among serum TC, LDL, TG, HDL, CEA, CA199 levels in gastric cancer group; Probing into the relations between lipids, lipoproteins and tumors.4 Statistical analysis methods:With SPSS16.0 statistical package, using single factor analysis of variance (ANOVA) or Kruskal-Wallis test among multiple comparisons, using t-test between two groups and using correlation analysis between the relationship of variables.The measured are written asχ±s,and P<0.05 was considered statistically significant.Results①The levels of serum TG, TC, HDL, LDL, CEA, CA199 in non-tumor patients (normal control group and benign disease group) are in normal ranges, but CA199 level of benign gastric disease group is relatively higher than the healthy group's.②Serum TG, CEA, CA199 levels in gastric cancer are higher than that of non-tumor patients, while TC, HDL, LDL levels decrease.③Serum TC, LDL levels in gastric postoperative group are higher than that of preoperative group.④The relationship between the levels of serum TC, HDL, LDL, CEA, CA199 in gastric cancer and the clinicopathological stages is found. The scrum TC, LDL levels are negatively correlated with the CEA, CA199 levels.ConclusionsThe metabolism of blood-lipid and lipoprotein in gastric cancer patients' serum is disordered. The levels of blood-lipid, lipoprotein and CEA,CA199 of gastric cancer can be used as important supplementary indicators in improving the diagnosis rate, judging the stages of clinical pathology, and evaluating curative effect and prognosis.