| Objective:To explore the level of serum adenosine deaminase (ADA) in jaundice yang huang patients and clinical significance of the serum adenosine deaminase, which is useful for jaundice differentiation and identifying jaundice.Methods:Selected 64 cases of jaundice yang huang patients, witch were included damp-heat syndrome,gall-bladder organ depressed heat syndrome and pestilential toxin flaming syndrome, then divided them into 34 cases liver cellular jaundice and 34 cases obstructive jaundice according to western medicine diagnosis standard. To register the general data, laboratory results and auxiliary examination results with unified form, which mainly included serum ADA, common hepatic function index. Carried on the statistical comparison with SPSS16.0.Conclusion:1. Chinese medical syndrome:TCM Syndrome jaundice yang huang patients with damp-heat syndrome in the main, including damp heavier heat syndrome, a total of 21 cases, accounting for30.9%, and heat heavier damp syndrome, a total of 23 cases, accounting for 33.8%, followed by gall-bladder organ depressed heat syndrome, a total of 20 cases, accounting 24.9%, and pestilential toxin flaming syndrome for at least a total of 4 cases, accounting for 5.9%.2. Serum ADA:In the jaundice yang huang patients, damp-heat syndrome serum ADA (23.42±13.23 U/L) higher than gall-bladder organ depressed heat syndrome (15.13±12.60 U/L), and both had significant difference (P=0.022<0.05).Serum ADA level of liver cellular jaundice group (30.55±12.79 U/L), higher than obstructive jaundice group (12.15±5.28 U/L), and both have extraordinary significant difference (P=0.000< 0.01). The positive detection rate of serum ADA in liver cellular jaundice group was 91.18% (ADA>15.0U/L for position), higher than obstructive jaundice group 23.53%.3. TBIL,DBIL,IBIL, DBIL/TBIL rate:Total bilirubin level of obstructive jaundice group (131.10±80.18umol/l),higher than liver cellular jaundice (115.81±64.74 umol/l),but both have no significant difference (P=0.581>0.05); Direct bilirubin level of obstructive jaundice group(80.98±54.95 umol/l),higher than liver cellular jaundice group(62.04±51.79 umol/l, but both have no significant difference (P=0.114>0.05);Indirect bilirubin level of liver cellular jaundice group (52.14±24.78 umol/l),higher than obstructive jaundice group (49.41±33.92 umol/1),but both have no significant difference (P=0.160>0.05);Direct bilirubin/Total bilirubin rate of obstructive jaundice group (0.59±0.15),is higher than liver cellular jaundice group (0.49±0.16), and both have significant difference (P=0.017<0.05).4. ALP:ALP level of obstructive jaundice group (202.66±143.88U/L), is higher than liver cellular jaundice group (155.79±87.47U/L), but both have no significant difference (P=0.303>0.05). 5.y-GT:y-GT level of obstructive jaundice group (323.14±286.23 U/L),is higher than liver cellular jaundice group (155.96±145.29 U/L), and both have significant difference (P=0.010<0.05).6.ALT,AST:ALT,AST level of liver cellular jaundice group (364.82±577.78U/L,270.37±408.91U/L), are higher than obstructive jaundice group (257.14±346.56 U/L),but both have no significant difference (P=0.825>0.05,P=0.573>0.05).Conclusion:1. Jaundice yang huang symptoms characteristic of Chinese medicine to the most prevalent damp-heat syndrome, followed by gall-bladder organ depressed heat syndrome. Yang huang occur in more closely with the damp and heat.2. In the jaundice yang huang patients, serum ADA level between damp-heat syndrome and gall-bladder organ depressed heat syndrome has significant difference. Serum ADA is useful for identifying jaundice.3. In the jaundice yang huang patients, serum ADA level between liver cellular jaundice group and obstructive jaundice group have extraordinary significant difference, and both positive inspection rates also have significant difference.4. Common hepatic function index, such as TBIL,DBIL,IBIL,ALT,AST,ALP, between liver cellular jaundice group and obstructive jaundice group had no significant difference.5. Common hepatic function index, such as y-GT and DBIL/TBIL rate between liver cellular jaundice group and obstructive jaundice group had significant difference.6. Compared with common hepatic function index, serum ADA between liver cellular jaundice group and obstructive jaundice group had extraordinary significant difference. United detection serum ADA and DBIL/TBIL rate was more useful to identify liver cellular jaundice and obstructive jaundice.7. Above all, serum ADA for jaundice differentiation and identify jaundice had important clinical significance. |
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