| Objective:By adjusting the amount of the medicines, the thesis uses Miscarriage Prevention Bolus and Decoction for Preventing Abortion to treat colporragia during pregnancy and fetal irritability caused by the weakness of both the kidney and the spleen. The author observes the improvement in the clinical symptoms by this treatment, so as to investigate the medicine's influences to the level of the progestin (P).Methods:The author observes 60 threatened abortion cases which correspond with the syndrome differentiation and diagnosis criteria. The patients are randomly divided into two groups: the experimental group with 30 cases, and control group with 30 cases. There is no significant difference between the two groups before the treatment.The patients in the experimental group (Chinese medicine treatment group with progestin) take orally one dose of the adjusted Miscarriage Prevention Bolus and Decoction for Preventing Abortion every day, divided into two to take. What is more, the patients also need to take 20mg of progestin by intramuscular injection once per day.The control group, i.e. the western medicine therapy group, are injected into muscle 20mg of Progesterone once or twice every day. Meanwhile, the patients in this group take 100mg of Vitamin E orally once a day.The author takes two weeks as a course of treatment. Both of the groups use the designed treatments for two courses. If after two courses of the treatments, the improvement of the sydromes is unconspicuous, however, the B-scan ultrasound shows that the embryonic development is normal, the treatments can be continued by one to two courses. The thesis compares the patients'situations before and after the treatment by improvement of the abdominal pain, distress in the loins, colporrhagia and TCM syndrome scoring, as well as the P value changes of the serum. By comparison, this paper evaluates the clinical curative effects of the two therapies.Results:By comparison, the total effective rates in the experimental group and the control group have no significant difference (P > 0.05). That is to say, both therapies have the similar effect to colporragia during pregnancy and fetal irritability.(1) Comparison between groups:①Before treatment, P value of the serum, ages and gestational weeks of the patients, the TCM syndrome scoring, etc. have no significant differences (P > 0.05).②After treatment, the total effective rates in the experimental group is 83.33%, while the total effective rates in the control group is 73.33%. There are no obvious difference between the two groups (P>0.05).③After treatment, the P value of the serum have significant difference (P < 0.05).④After treatment, the improvement time of both groups in abdominal pain, and distress in the loins, as well as TCM syndrome scoring are greatly different (P < 0.05).⑤After treatment, the time of the vaginal blood check of both the groups have no significant difference (P > 0.05).(2) Comparison within group:①The TCM syndrome scorings and P value of the serum before and after treatment in the experimental group have great difference (P < 0.01).②The TCM syndrome scorings and P value of the serum before and after treatment in the control group have significant difference (P < 0.01).③The levels of P value of the serum in the patients who have protected the fetus successfully are rising, while those in the patients who have failed to protected the fetus are decreasing. Both groups have significant difference before and after treatment (P < 0.05). This result proves that both the therapies serve the function of protecting the fetus through improving the levels of P value of the serum.(3) B ultrasonic monitoring results can objectively reflect the clinical efficacy of treating fetal irritability of the therapy: The B ultrasonic monitoring results of the patients who have protected the fetus successfully shows that the pregnancy sac can be seen, and the embryo and original heart tube throb in the pregnancy sac can also be seen, as well as the echo of the forming fetus. The size of the womb, the development of the pregnant sac and embryo(fetus) accord with the weeks of the pregnancy. Seen from the B ultrasonic monitoring pictures, the embryo in the uterine cavity of those who have failed to protect the fetus stops growing, and the pregnancy sac withered, and the the echo of the forming fetus disappears. The size of the womb does not agree with the weeks of pregnancy.Conclusion:(1) The experimental group with the adjusted amounts of Miscarriage Prevention Bolus and Decoction for Preventing Abortion therapy and the control group treated with progestin have similar effects. Both of them can improve the symptoms of vaginal bleeding, waist sour and syndromes aspects of the situation in Chinese medicine. They can also improve the P value of the serum, increase the succussful protection of the pregnancy rate of the colporragia during pregnancy and fetal irritability caused by the weakness of both the kidney and the spleen. However, compared with the treatment of progestin, the therapy of the adjusted amounts of Miscarriage Prevention Bolus and Decoction for Preventing Abortion therapy has a better effect on improving the symptoms of waist sour, abdominal pain, syndromes aspects of the situation in Chinese medicine and P value of the serum. Furthermore, it has relatively higher safety rate, and is of small toxic effect. Therefore, it worths further research and application.(2) The applying of P value of the serum and the use of B ultrasonic can accurately judge the therapeutic effect to the colporragia during pregnancy and fetal irritability. What is more, the P value of the serum has a positive correlation with the succussful protection of the pregnancy rate.(3) Monitoring the changes of P value of the serum, it can be predicted that the therapy of adjusted amounts of Miscarriage Prevention Bolus and Decoction for Preventing Abortion works through improving the levels of P value of the serum to protect the pregnancy. |
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