Comparison Of Arterial Pressure's Measurement Methodology And Analysis Of Correlation Between Central Aortic Pressure And Severity Of Coronary Artery Lesion

Objective:1,To evaluate the relevance and conformity of measuring CAP by BProTM 6000 pulse wave analyzer and invasive catheterization, preliminary analysis the relationship of CAP and brachial arterial pressure. To study the relationship between central aortic systolic blood pressure (cSBP) measured by non-invasive technique and invasive catheterization and brachial aortic systolic blood pressure (bSBP) in different age groups.2,To study the correlation between the central pulse pressure(PP), the level of central pulse pressure index (PPI) and the severity of coronary heart disease(CHD), searching for the value of PP and PPI during the development of CHD, so that we can offer useful data and clue to the prevention and treatment of coronary heart disease.Methods:1,Collecting 62 patients admitted in cardiology department from August, 2010 to December, 2010,who underwent coronary artery angiography (CAG). There were 40 male patients and 22 female ones, aged 63.7±10.6 years old. Patients were also divided into two groups by more or less than 60 years old. CAP were measured by invasive catheterization and non-invasion BProTM6000 arterial pulse wave analyzer, respectively, and brachial arterial pressure were measured by E-cuff blood pressure monitor. To compare the three value of brachial arterial pressure, CAP by non-invasive technique and invasive catheterization.2,153 patients who underwent coronary artery angiography (CAG) due to suspected or diagnostic coronary artery disease were enrolled, of them 92 male and 61 female, average aged 64.32士9.75 years old. Clinical various biochemical indicators of all patients were gained in check-in hospital,and height, weight, essential hypertension (EH) history, diabetes history and smoking history were recorded. Central BP including systolic blood pressure (SBP) ,diastolic blood pressure (DBP) and mean blood pressure (MAP) was measured during the period of coronary angiography, then pulse pressure and pulse pressure index were calculated. The patients were divided into coronary heart disease (CHD) group and control group by the result of CAG. According to the number of suffered coronary artery, Patients were divided into one-vessel pathological, two-vessel pathological and three-vessel pathological. All subjects were divided into four groups in accordance with the quartile method of PP and PPI respectively, comparing different of coronary artery lesions classification in different groups.A multivariate logistic regression analysis was performed to evaluate the independent effects of hemodynamic variables on the risk of having three-vessel in CHD, in which the center arterial pressure and age, gender, BMI and smoking, high blood pressure, diabetes and high cholesterol were as independent variables.Results:1,In the overall group and subgroup aged <65 years old, cSBP measured by non-invasive technique and invasive catheterization have no significant difference(P all>0.05), then comparison is significantly different in the sub-group aged≥65 years(P<0.05). Compared with cSBP1, bSBP of the overall group and subgroup aged <65 years was significantly greater than cSBP1, differences were statistically significant (P all <0.05). then them have no significant difference in the sub-group aged≥65 years (P>0.05).2,the proportion of CHD group combined hypercholesterolemia, smoking, hypertension, diabetes and the average age of CHD group were more than the control group(P<0.05). With the increasing of PP and PPI,the prevalence of CHD was increasing, and coronary artery lesions gradually increase the number of classification. After multivariate logistic regression, central PP, PPI, age and DM were independently related to the risk of having three-vessel coronary artery disease in CHD(PP per 10 mmHg, OR=1.171,95%CI=0.135 to 1.214; PPI per 0.1, OR=1.235, 95% CI=1.152 to 1.327;P all<0.05).Conclusions:1,Noninvasive aortic cSBP close to the actual value measured by invasive catheterization, And reproducibility and stability of the value measured by noninvasive technique is very good if objective conditions remain unchanged in a short time.But for different age groups the accuracy of noninvasive measurements are some differences.2,Coronary heart disease is the result of multiple factors. central PP and PPI were related to the three-vessel disease in patients with CHD,central PP and PPI were risk factors of the three-vessel disease in patients with CHD.