Association Of Aortic Pulse Pressure And Pulse Pressure Index With The Degree Of Coronary Artery Disease

Objective:To assess the relationship between the function of coronary artery and blood pressure of aorta and brachial artery. On the one hand, the measuring object of so-called arterial pressure that we usually refer to aortic blood pressure, in the clinical practical, actually, is brachial artery. That is to say, we assumed brachial arterial pressure could accurately reflect aortic blood pressure; and such an assumption is closely related to the coronary arterial function. On the other hand, some epidemiology investigations, such as Framingham Study and INTER-HESRT Study, all found that coronary disease is attributed to multiple factors. The multi-factor study about the two, cardio-arterial pressure and coronary artery disease, in the golden standard measurement which reflects the arterial pressure, have not been reported so far. In these circumstances, it cannot be comprehensive that only to discuss the relationship between coronary disease and blood pressure of aorta and brachial artery. Therefore, the purpose of the study was to objectively reflect the real position of arterial pressure in the studying fields of coronary disease.Methods:166 cases of coronary artery disease between Mar.2008 to Sept.2009 were diagnosed by placing coronary angiography catheter on aortic root and measuring the pressure. The patients'lesion degrees of coronary artery have been evaluated by Gensisi scoring system and occurrence of severe diseases,which included triple vessel and left main disease. When applying SPSS 17.0 software to analyzed single factor and multivariate Logistic regression. The purpose is to remove the confounding factors.Results:we find that the factors such as age, increasing aortic pressure, diabetes and high pulse pressure index of peripheral artery arrayed in ascending order, were correlated positively with the increasing scores of coronary artery. And sex, exceeding BMI and dyslipidemia are of little relevance. In the above factors, diabetes makes patients of CHD more vulnerable to both three-vessel coronary artery diseases-4.008 times than normal range, and left main coronary artery disease-3.968 times than normal range. For three-vessel coronary and left main coronary artery disease, there is also a correlation between such diseases and the high aortic pressure which is 2.105 times and 3.560 times higher than the low aortic pressure.Conclusion:It is suggested the index of peripheral arterial pressure is trustworthy. The high aortic pressure, on the one hand, aggravates the damage done by coronary arterial stenosis, and on other hand, maintains the blood perfusion even after complex lesions. The correlation between diabetes and the coronary disease mainly related to the vessel lesions.