| Research purposeTiao-zhi-kang decoction prophase clinical observation, found Tiao-zhi-kang decoction has good lipid role, with no obvious side effects. At present the Chinese adult dyslipidemia control guidelines recommend cholesterol-lowering drugs (statins) although clinical curative effect is good, but the recommended dose (atorvastatin calcium: 10mg)for some lipid levels increased significantly higher and triglyceride hyponatremic patients who have no obvious curative effect, if increase its treatment usage (atorvastatin calcium intensie treatment:80mg) although can be significantly improved treatment effect, but increased significantly toxicity, long-term use can cause gastrointestinal dysfunction, muscle pain, adverse reactions such as abnormal liver function, appear even rhabdomyolosis severe toxicity reaction. In addition, this kind of western medicine price is on the high side, increase the dose against patients long-term use, so think research and development of dyslipidemia effective the TCM treatments is significant, especially for lipid levels increased significantly, and the high triglycerides hyponatremic patients, it has the obvious curative effect medicine combination therapy. Research methodsClinical collecting 119 patients in wuhan TCM hospital. Patients'blood lipid in check:in normal diet cases, detection of fast after 12 hours to decide whether its' blood fat level is abnormal, there must be a dyslipidemia 2 weeks at least 2 times a specimen of blood test records. Patients will be selected randomly divided into three groups, cases in treatment group:give since fitting tiaozhi kang oral liquid (preparationed by pharmaceutical preparation department of Our hospital) combination therapy with atorvastatin calcium (Beijing ka lam pharmaceutical Co., LTD., brand name:ALe), methods:tiaozhi kang oral liquid 10ml every time, three times a day, oral; Atorvastatin calcium 10mg, once a day, each oral. The control group (一):give atorvastatin calcium quantity of 10mg (standard treatment dosage, once a day, each oral). The control group (二): give atorvastatin calcium quantity of 80mg (intensie treatment volume), once a day, each oral. Three groups are in a month for one period of treatment, a month for treatment. The lipid index observed before and after treatment, efficacy judgment and toxicity three aspects of the situation.Research resultsClinical curative effect aspects:1. Tiao-zhi-kang decoction joint atorvastatin calcium 10mg on lowering blood fat of the four indexes like TC, TG have such good result, and particularly advantage in droping TG level. Compared with intensie treatment group has a equal effect, Compared with the standard treatment group has a better effect.2. Tiao-zhi-kang decoction joint atorvastatin calcium 10mg group compared with standard treatment group the total effective rate is better, and compared with intensie treatment group the total effective rate Roughly the same.Clinical side effects aspects:Tiao-zhi-kang decoction joint atorvastatin calcium 10mg Compared with standard treatment group has much the same side effects. Compared with intensie treatment group has more smaller side effects.Research ConclusionDyslipidemia illness evil nature in sputum syndrome, blood stasis, aided by phlegm, stasis reasons and for surface root cause is viscera is deficient and function disorder, especially in the liver, spleen and kidney three dirty primarily. Tiao-zhi-kang decoction have fall turbidity Richard spleen, phlegm,. and function of lipid. This research shows that:this prescription can used together with atorvastatin calcium, among the two drugs, without apparent drug reaction, and increased lipid-lowering effect, expanded the scope of drug therapy, and no significant side effects. The increased significantly in lipid levels and high triglycerides hematic disease's treatment has the obvious advantage, besides it can obviously reduce costs, so, it is worth the clinical promotion use. |
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