Integrative Clinical Study, The Treatment Of Kidney Deficiency In Elderly Hypertensive Patients Antihypertensive Efficacy Of Early Renal Damage

Objective:we examined and evaluated the antihypertensive effects of treatment with integration of traditional Chinese medicine and western medicine on elder patients with hypertension, as well as the intervention on corresponding renal damage. On this basis, we conducted a clinical randomized controlled trial, in order to clarify the antihypertensive effect of Longevity Antihypertensive Liquid integrated with western medicine on hypertension patients with kidney deficiency in the elderly, and its intervention on the improvement of renal damage.Method:using the method of computer randomization and effective drug controlling,72 elder patients with hypertension of kidney deficiency syndrome were recruited, and with a ratio 1:1 randomly assigned them into two groups, namely,36 patients in treatment group and 36 patients in control group. We served the control group with normal treatment with western medicine (a combination of Extended Release Nifedipine Tablets and Enalapril Maleate Tablets). On the other hand, we gave the same treatment with supplement of Longevity Antihypertensive Liquid to each patient in the treatment group. After 6-month treatment period, we observed before and after the treatment to compare and discuss the changes in 24-hour ambulatory blood pressure, five items of renal damage and Cystatin C levels for both groups.Results:Through the comparison, we found that there is no significant difference between the case group and the control group in the terms of antihypertensive effects with significant level of 0.05. However, significant change had been observed before and after the treatment in each group(P<0.05). Specifically, there were significant decrease in 24-hour ambulatory blood pressure, day blood pressure mean, night blood pressure mean, day blood pressure load and night blood pressure load after treatment for the treatment group (P<0.05 or 0.01); indicators had significant changes in control group except for day SBP mean, night SBP mean,24h SBP mean as well as day SBP load mean. In addition, the treatment group had better performance in antihypertensive effects in day, night, and 24h systolic pressure than that of control group based on the comparison between groups after treatment(P<0.05). For comparing indicators of renal damage, both of groups presented significant decrease in MALB, IgG, and TRF with p-values less than 0.01 or 0.05, however, decrease ofβ2-MG in the treatment group was significant compared to that of control group at significant level of 0.05.Conclusion:Longevity Antihypertensive Liquid integrated with normal western medicine has favorable effects of antihypertension and improvement of renal damage of patients with hypertension in the elderly, which is worthy of clinical application and popularization.