Study On The Relationship Between Epidermal Growth Factor And Late-onset Breast Milk Jaundice Of Full Term Neonates

Objective: To discuss the relationship between epidermal growth factor (EGF)and late-onset breast milk jaundice and to select the optimal site of transcutaneousbilirubin measurement.Methods: A total of75neonates with late-onset breast milkjaundice(experimental group) and25controls(normal neonates at the same days)were enrolled from the pediatric outpatient department of our hospital. Aim to findthe difference of the EGF in breast milk and serum of the two groups. A total of30neonates with late-onset breast milk jaundice had been intervented of stopping breastmilk for almost72h. Aim to find the difference of the EGF in breast milk and serumand serum total bilirubin in the neonates with stopping breast milk. Elisa method wasused to detect the concentration of EGF. At the same time,the forehead and chesttranscutaneous billirubin were measured by the transcutaneous bilirubinometer ofJH20-1C, the mean of forehead and chest transcutaneous bilirubin recorded asforehead-chest transcutaneous bilirubin.Compare the values of TcB with differentsites and TSB to select the optimal site of transcutaneous bilirubin measurement.Andfind the differences bettwen the values of TcB with different sites and TSB.Results: The experimental group total bilirubin, serum and breast milk EGFwere higher than those in the control group. The values were233.16±41.93u mol/LVS115.7±33.89umol/L(P <0.01);556.37±169.5pg/ml VS493.24±159.82pg/ml;338.59±99.87pg/ml VS317.92±85.70pg/ml(P>0.05) respectively. In30pairedsamples after stopping breast-feeding serum total bilirubin and EGF concentrationdecreased. Serum total bilirubin was228.82±41.07umol/L VS159.05±48.74umol/L(P <0.001), dropped about24.83%-36.48%; serum EGF concentration was502.27±188.40pg/ml VS444.81±134.18pg/ml(P=0.023, P <0.05); milk EGFconcentration did not change. Breast milk EGF concentration was343.50±95.23pg/mlVS338.81±104.03pg/ml(P=0.805, P>0.05). The forehead, forehead-chest, chesttranscutaneous bilirubin measurement values were positively associated with the serum bilirubin values(r-额=0.815,P<0.001；r_额胸=0.812,P<0.001；r胸=0.798,P<0.001).The forehead, forehead-chest, chest transcutaneous bilirubin were higher than totalserum bilirubin, approximately2.13,0.98,1.53mg/dL, respectively. The site of chestwas the optimal site of transcutaneous bilirubin measurement.Conclusion: Epidermal growth factor maybe related to the occurrence of lateonset breast milk jaundice. Chest could be as the optimal site of transcutaneousbilirubin measurement. TcB is about1-2mg/dl higher than TSB. In the clinicalapplication of percutaneous diagnosis and treatment, we should consider thedifference between TcB and TSB.