| Purpose Bladder transitional cell carcinoma (bladder transitional cellcarcinoma, BTCC) is China’s highest incidence of urinary system malignant tumors.To high-risk, frequent recurrence, for its characteristics, superficial tumors easyrelapse, metastatic infiltrating and with poor prognosis. In recent years the surgery andchemotherapy for is to constantly improve the curative effect but are not satisfied.Tumor new blood vessels in the tumor biological characteristics of important role isbeing more scholars’ attention. CD105and Endoglin name, as promoting tumorangiogenesis of one of the most important factors, is a new endothelial cell adhesionmolecule. Platelet c-reactive protein-1TSP-1) is a kind of important inhibitsangiogenesis material, and in the human tissues widely distributed. Research CD105,platelet c-reactive protein1(platelet c-reactive protein-1, TSP-1) in human transitionalcell carcinoma (TCC) tissue of the expression and their clinical significance. In orderto study the new bladder tumor blood vessels for transitional cell carcinoma (TCC)treatment with new ways.Methods To collect from January2009to October2011henan university ofscience and technology are the first affiliated hospital uropoiesis surgical departmentand60cases of postoperative histopathologic examination both confirmed fortransitional cell carcinoma of the bladder tissue samples as BTCC group,34patientswith men, women26cases, aged27~79years, mean age58.43years old. Tumorspecimen group according to the world health organization (WHO) classificationstandard G1:24patients, G2:21cases, G3:15cases. According to TNM staging Tis~T1:39cases, T2-T4:21cases. And choose normal bladder mucous membrane,10cases of organization as control group.10cases of normal bladder mucous membranefrom traumatic urethral tissue repair and bladder surgery forces of the specimen.BTCC group and control group age and gender no significant differences. Chooseimmunohistochemical method to detect SP60cases BTCC and10cases of normalbladder tissue CD105, TSP-1of expression, and according to the transitional cell carcinoma (TCC) organization of different classification, staging lesions comparisonand relevance of data analysis. Application SPPS17.0statistical software processingall the data results and to perform a chi-square test, P <0.05said differences aresignificant.Results Bladder tumor tissue CD105positive expression mainly in cellplasma cell membrane and, focusing on the edge of the tumor cells and capillariesendothelial cells. CD105bladder urothelial carcinoma in the expression is stronger,and in normal bladder mucous membrane expressed weakly. Its MVD value were21.43±13.13and3.64±1.33. Both are statistically significant difference in (t=3.785,P <0.05). TBCC TSP-1in the positive dyeing is weak, especially the more tumorgrade high for the negative. In the bladder urothelial carcinoma and normal bladdermucous membrane of the difference in expression is statistically significant (P <0.05).Bladder tumor tissue TSP-1low expression in25; TSP-1high expression of bladdertumor tissue16MVD value is low, and CD105were also lower expression13cases.In CD105low-alcohol expression in the bladder tumor tissue TSP-1low expressionMVD value significantly higher than to the high expression TSP-1MVD value (P <0.05).Conclusion1. CD105high expression and MVD value high bladder tumortissue TSP-1low expression, TSP-1high expression of the bladder tumor tissue MVDvalue is low, and CD105expression is low. In CD105low-alcohol expression in thebladder tumor tissue TSP-1low to express was significantly higher than the TSP-1express high MVD value.2. The above shows the blood vessels of the bladder tumor formation is CD105and theTSP-1, as a representative of the positive and negative two kinds of vascularinteraction results. So both the tissue of bladder cancer were in expression and therelationship with MVD help determine the development of cancer and prognosis.3. And we can also study intervention in both the role of angiogenesis to achievebladder cancer antiangiogenesis therapy. About both in the role of tumor angiogenesisis in a stage of study, of which more link mechanism is not completely clear, we needto further research. |
