The Clinical Survey Of Take Orally Propranolol Treatmentin Infantile Hemangiomas

Objective The purpose of this study is to evaluave the short-term efficacy of propranolol in the treatment of infantile hemangiomas.Methods56infantile patients with hemangiomas of proliferative phase were collected from December2010to October2011,that treated in our Department of the First Affiliated Hospital of Guangxi Medical University. Clinical evalu-ation, electrocardiography, and experimental examination of liver function and heart function were performed before treatment. The daily dose of propra-nolol was increased from1mg/kg at the first day to1.5mg/kg at the seco-ndd day, given in2divided doses per day. Blood pressure and heart rate were monitored during the first12hours of treatment. Patients were hospit-alized for one week blood glucose and blood ALT,AST,BUN,CREA were monit-orred, and B ultrasound for deep-seated hemangiomas，If Various life signsStability, then continued medic-ation at home and revisited every months to observe the changes of tumor color, size,results were evaluated according to Achauer scale systemResult All the tumors decreased in color, size and density at24hours post-medication, and all cases had medication for a mean time of4months. The overall response was scale I in2patients, scale II in8patients,scale III in32patients, scale IV in14patients after following-up for3to8months.Conclusion The efficacy of propranol in the treatment of hemangiomas is excellent while the side effect is minimal, leading to considerable shortening of the natural course of IH.Propranolor can be considered to used as first line to treat infantile hemangioma during the proliferating phase.