Effects Of Aspirin On Healing Of Osteoporotic Fractures

Objective To research the effects of aspirin on healing process of ovariectomized rats with osteoporotic fractures.Methods60female Wistar rats which were3months old were dividied randomly into3groups:ovariectomized group50, pseudooperation group5, blank group5. The bilateral ovaries of ovariectomized group were resected; we do operation on peudooperation group without resecting bilateral ovaries, while adipose tissue with the same weight of two ovries were removed; do nothing with blank groupt.3months later, in order to verify whether osteoporosis models were successed bone mineral density of5rats randomly selected from ovariectomized group were detected, so are the pseudooperation group and blank group. After the osteoporosis models were built, we broke the left femur of ovariectomized rats at the midpoint, then used Kirschner wire to fix them intramedullary. Then the fracture model of50rats were divided into group A and group B (each group of25only), group A were lavaged with aspirin,33mg/time,1time/day, group B were lavaged with corresponding saline. Bone mineral density were detected at2th,4th,8th,12th week (each time we take five rats from each group) then we took callus and do histological examination. Besides we do radiology observation at8th,12th week. The biomechanics determination were done on the rest five rats of each group at12th week.Results①Bone mineral density values:The value of group A are higher than that of the group B at each time point;②Histologic observation:HE dyed, cartilage formation of group A is accelerated compared with group B;③Radiology observation:fracture line of group A were fuzzy while fracture line of group B is still clear after8weeks; fracture line of group A were disappear while fracture lines of group B were blurred After12weeks;④The biomechanics determination:, the three bending load of left femur of group A was higher than group B, after12weeks, the difference was statistically significant.Conclusions Aspirin can promote the healing process of ovariectomized rats with osteoporotic fractures, increase the bone mineral density and biomechanical strength.