The Correlation And Significance Of Serum Markers And Food Intolerance In Ulcerative Colitis

Background Ulcerative colitis is a heterogeneous group of inflammatory disorders of thegastrointestinal tract, and its etiology is undertermined. It is reported that the interaction amonggenetic gene, environment and immune system is involved in pathogenesis and verifies itsclinical phenotype of UC. The diagnosis of UC relies on clinical manifestation, colonoscopy,x-ray and biopsy. The correlation of food and serum markers in UC patients has been widelydrawn attention in recent years.Objective To analyze the clinical features from classification of patients with ulcerativecolitis (UC), and to estimate the relationships among those clinical features and perinuclearanti-neutrophil antibody (p-ANCA), and anti-intestinal goblet cell antibody (GAB). Toinvestigate the potential relationship between food intolerance (FI) and UC, and the correlationof FI, p-ANCA and GAB.Methods The analytical methodology for the retrospective study of117UC clinical cases isbased on the diagnosis and treatment criteria of IBD from Chinese consensus. It mentions theexamination of p-ANCA and GAB from all of the cases of which59UC cases will be involvedin the examination of the food intolerant IgG.Results The pancolitis and left-side (39.3%,23.9%) were obviously predominant in thisgroup. Moderate and severe patients (39.3%,38.5%) were common. About7.1%of patients hadextraintestinal manifestation. Generally speaking, the wider the range of lesion is, the moredramatical the lesion is, which forms the correlation in statistics(P<0.05). It was found that thepositive percentage from the resultant examination of p-ANCA and GAB in UC patients were50.4%and9.4%, respectively. The IgG-positive percent in59UC patients was up to86.44%andsatisfies the statistical difference between the UC group and disease control(P＜0.05). Comparedto the lesion location without the statistical difference (P>0.05). In terms of statistical data, thepatients with p-ANCA positive have higher probability of food intolerance than do those with GAB positive.Conclusions The positive results from the examination of p-ANCA and GAB isindependent on gender and age of UC patients, clinical features, ertraintestinal manifestations,lesion range and degree (P>0.05). The correlation of the food intolerance and UC pathogenesis isexplicit but not related to the lesion location. Meanwhile, it is not observed that p-ANCA, GABis statistically related to FI. The patients with p-ANCA positive have high probability of FI.