The Diagnostic Significance Of Serume Autoantibody Detection In Ulcerative Colitis

Objective: The purpose of this study is To investigate the effects of anti-Saccharomyces cerevisiae antibody(ASCA),anti-pancreatic acinar antibody(PAB),anti-intestinal goblet cell antibody(GAB)and anti-neutrophil cytoplasmic antibody(pANCA)in ulcerative colitis(UC),To discuss the diagnostic significance of serum autoantibody detection in UC and its relationship with the clinical features of the disease.Methods: From January 2011 to January 2016,173 patients with UC were diagnosed,and 54 patients with normal colonoscopy were taken as the control group.The expression of four kinds of antibodies in serum were detected by indirect immunofluorescence method.And analyze the relationship between them and clinicopathological factors.Results: The positive rate of p ANCA in UC group was 58.3%,higher than that in control group(P <0.05).The positive rate of GAB in UC was 30%(12/54),higher than that in control group(P <0.05).The positive rate of combined detection of UC and UC was 64.8%.ASCA and PAB in the UC group and control the difference was not statistically significant.The sensitivity and specificity of p ANCA(+)for diagnosis of UC were 58.3%,98.14% respectively.It is slightly elevated in patients with severe disease and extensive lesions.The sensitivity and specificity of UC were 32.36%,90.74%.The sensitivity ?specificity of combined detection of P-ANCA and GAB were 75.14%,88.88% respectively.Conclusion: The specificity of ANCA,GAB,ASCA and PAB is high,but the sensitivity is low.The combination of p ANCA and GAB is valuable for the diagnosis of UC,and the combined detection of pANCA and GAB can improve their expression rate while improving the sensitivity of UC diagnosis.PAB for the diagnosis of UC is not significant.The positive rates of these four antibodies were not related to age,sex,disease severity,disease stage,clinical type,extent of lesions,parenteral manifestations,complications,and so on(P > 0.05).