The Clinical Study Of Supplementing Qi And Nourishing Yin Treatment In Patients With Type Of Deficiency Of Both QI And YIN Of IgA Nephropathy

BackgroundIgA nephropathy (IgAN) is a special type of Mesangial lesions, which IgA or IgA-based immunoglobulin diffuse deposition in the glomerular mesangial area or capillary loops caused by a series of clinical symptoms and pathological findings.At present, domestic expert consensus, as well as Kidney Disease: Improving Global Outcomes (KDIGO) clinical guidelines are mainly concentrated in the ACE inhibitors, ARB drugs, glucocorticoids immunosuppressant fish oil, anticoagulant and antiplatelet drugs, tonsillectomy surgery such. However, there is no clearly effective treatment for simple hematuria patients or who has few proteinuria. Both Western medicine and Chinese medicine can indelaying the progress of kidney disease in their respective fields. Large amounts of data show that Integrative Medicine has good prospects in IgAN treatment.ObjectivesBy observed to selected cases before and after treatment in clinical symptoms, laboratory tests to observe the total effect to explore the curative effect of Chinese medicine intervention.MethodsWe collected41IgA nephropathy patients in ours hospital(The Chinese hospital in guangdong province) by the way of the method of itself comparison prospective study. In Western medicine basic treatment, we gave pations whose proteinuria>0.5g ACEI or ARB. If the patients whose Proteinuria still more than1g/d After3-6month a reasonable supportive therapy Including ACEI or ARB and control of blood pressure), gave them glucocorticoid treatment for6month. In some high risk patients (such as GFR<50ml/min, Deterioration of renal function, lots of proteinuria,), give Corticosteroids add cyclophosphamide (followed by azathioprine) after of antihypertensive and antiproteinuric treatment. In Chinese medicine, give patients a decoction of medicinal ingredients of Supplementing qi and nourishing yin Treatment for8weeks. Comparative analysis of the symptoms and related indicators between before and after treatment. After8weeks, evaluate the efficacy of disease, symptoms, urinary protein and urinary red blood cell.Result1The frequency analysis of the preliminary findings showed that there had12(29.3%) male and29(70.7%) female in the41patients, the minimum Age was22, the maximum age was61, the mean age was36.88±10.67. the minimum course of disease was22month, the maximum course of disease was168month, the mean course of disease was40.63±42.17month.2After the treatment, total symptom score, laboratory teests such as the24hour total urinary protein, qualitative urinary protein, qualitative and quantification of Urinary red blood cell were improved over the previous, all of these were significant different(P<0.01)3In the efficacy of symptoms, there were2cases (4.9%) clinical control,31cases (75.6%) markedly effective,8cases (19.5%) effective.4In the efficacy of disease, there were9cases (30%) clinical control,15cases(36.6%)markedly effective,11cases(29.3%)effective, total effective rate was87.8%.5In the efficacy of urinary protein, there were6cases (20%) clinical control,4cases (13.3%) markedly effective,12cases (40%) effective, total effective rate was73.3%.6In the efficacy of urinary red blood cell, there were3cases (8.1%) clinical control,15cases(40.5%)markedly effective,8cases(21.6%)effective, total effective rate was70.3%.Conelus ionThe treatment on the combination of TCM with Western medicine in IgAN can effectively relieve symptoms, reduce proteinuria, reduce urinary red blood cells, and improve the disease. Though compared with itself before and after, The Study on the Exploratory of Supplementing qi and nourishing yin Treatment in patients with type of deficiency of both QI and YIN of IgA nephropathy can still achieve a satisfactory effect.