The Law Of Evolution Of The Syndrome Caused By Yin-pathogenic Factor Regarding To The Lung Disease

Objective：Through searching and screening a lot of breathing medical records inrespiratory ward during June2010to December2011in Shandong university oftraditional Chinese medicine first affiliated hospital, select the lung diseases whichcommon appeared in our hospital (include asthma, chronic obstructive pulmonary diseaseand idiopathic pulmonary fibrosis), study the law of evolution of the syndrome caused byYin-pathogenic factor and find out the rules of syndrome evolution and coexistence. It canprevent the disease to become worse and guide the therapies and tendency so fill gaps athome and abroad.Methods: Abiding by the principle of random sampling, searching and screening alot of breathing medical records in respiratory ward during June2010to December2011in Shandong University of traditional Chinese medicine first affiliated hospital. Chooseacute exacerbation disease including asthma, chronic obstructive pulmonary disease andidiopathic pulmonary fibrosis60cases in each, record predisposing factors andsyndromes and screening these cases according to inclusion and exclusion criteria, afterthat, we evaluate the syndrome in remission and record the statistics. Using the statisticsdraw tables and analyzing the data by SPSS17.0to conclusion the results.Results:1About yin-pathogenic factorIn three kinds of Yin evil influence, phlegm (48.59%)> phlegm plus stasis(42.25%)>Han evil influence plus phlegm plus stasis (6.34%)> Han evil influence(1.41%)> stasis (0.70%)=Han evil influence plus phlegm> Han evil influence plus stasis(0%).2About evolution of the syndrome During acute exacerbation of asthma, there are10kinds of syndrome, syndrome ofphlegm-heat retention in the lung(40.48%)>syndrome of deficiency of lung-qi plusphlegm-heat retention in the lung (14.29%)> syndrome of deficiency of lung-qi plusphlegm and stasis retention in the lung(11.91%)>syndrome of phlegm retention in thelung(9.52%)=syndrome of phlegm and stasis retention in the lung>syndrome of deficiencyof lung-qi plus deficiency of kidney-yang(4.76%)>syndrome of deficiency of spleen-qiplus phlegm retention in the lung(2.38%)=syndrome of deficiency of lung-qi and spleen-qiplus heat-phlegm retention in the lung=syndrome of deficiency of kidney-yang plusphlegm and stasis retention in the lung=syndrome of deficiency of kidney-yang plusphlegm retention in the lung. The syndrome of excess in superficiality accounts for59.52%;the syndrome of deficiency in origin and excess in superficiality accounts for35.71%; the syndrome of deficiency in origin accounts for4.76%.The excess insuperficiality are phlegm(71.43%)>phlegm plus stasis(21.43%)> stasis(0%).The syndromeof deficiency in origin shows the syndrome of deficiency of lung-qi (26.19%)>syndromeof deficiency of kidney-yang(4.76%)=syndrome of deficiency of lung-qi and kidney-qi>syndrome of deficiency of spleen-qi (2.38%)=syndrome of deficiency of lung-qi andspleen-qi. According to research, the lung appears39person/times (92.86%)> the kidney4person/times(9.52%)>the spleen2person/times(4.76%).During remission of asthma, thereare8kinds of syndrome, syndrome of deficiency of lung-qi and kidney-qi(35.71%)>syndrome of deficiency of lung-qi and spleen-qi(19.05%)>syndrome of deficiency oflung-qi plus deficiency of kidney-yang(16.67%)>syndrome of phlegm retention in thelung(11.91%)＞syndrome of deficiency of lung-qi plus phlegm and stasis retention in thelung(7.14%)>syndrome of phlegm and stasis retention in the lung(4.76%)>syndrome ofphlegm-heat retention in the lung（2.38%）=syndrome of deficiency of kidney-yang plusphlegm and stasis retention in the lung. The syndrome of deficiency in origin accounts for71.43%; the syndrome of deficiency in origin and excess in superficiality accounts for9.52%; the syndrome of excess in superficiality accounts for19.05%. The excess insuperficiality are phlegm (14.29%)=phlegm plus stasis (14.29%)> stasis (0%). Thesyndrome of deficiency in origin shows the syndrome of deficiency of lung-qi andkidney-qi(35.71%)> syndrome of deficiency of lung-qi and spleen-qi(19.05%)>syndromeof deficiency of lung-qi plus deficiency of kidney-yang (16.67%)>syndrome of deficiencyof lung-qi(7.14%)>syndrome of deficiency of kidney-yang(2.38%). The lung appears41 person/times (97.62%)> the kidney23person/times (54.76%)>the spleen8person/times(19.05%).During acute exacerbation of COPD, there are10kinds of syndrome, syndrome ofdeficiency of lung-qi and kidney-qi plus phlegm and stasis retention in the lung(23.21%)> syndrome of phlegm-heat retention in the lung(21.43%)>syndrome ofdeficiency of lung-qi plus phlegm and stasis retention in the lung(12.50%)>syndrome ofphlegm and stasis retention in the lung(10.71%)>syndrome of deficiency of spleen-qi plusphlegm retention in the lung(7.14%)=syndrome of deficiency of lung-qi plusphlegm-heat retention in the lung>syndrome of phlegm retention in the lung (5.36%)=syndrome of deficiency of spleen-yang and kidney-yang plus phlegm and stasis retentionin the lung>syndrome of deficiency of lung-qi and spleen-qi plus heat-phlegm retentionin the lung(1.79%). The syndrome of excess in superficiality accounts for37.50%;thesyndrome of deficiency in origin and excess in superficiality accounts for62.50%; thesyndrome of single deficiency in origin accounts for0%.The excess in superficiality arephlegm plus stasis(57.14%)>phlegm(42.86%)>stasis(0%).The syndrome of deficiency inorigin shows the syndrome of deficiency of lung-qi and kidney-qi (23.21%)>syndrome ofdeficiency of lung-qi(19.64%)>syndrome of deficiency of spleen-yang and kidney-yang(10.71%)>syndrome of deficiency of spleen-qi (7.14%)>syndrome of deficiency oflung-qi and spleen-qi (1.79%).The lung appears50person/times(89.29%)>the kidney19person/times (33.93%)>the spleen11person/times(19.64%). During remission of COPD,there are11kinds of syndrome, syndrome of deficiency of lung-qi and kidney-qi(26.79%)> syndrome of deficiency of lung-qi and spleen-qi (21.43%)>syndrome of deficiency ofspleen-yang and kidney-yang plus phlegm and stasis retention in thelung(16.07%)>syndrome of deficiency of spleen-qi plus phlegm retention in thelung(10.71%)>syndrome of phlegm and stasis retention in the lung (7.14%)>syndrome ofphlegm-heat retention in the lung(5.36%)> syndrome of deficiency of lung-qi plusphlegm and stasis retention in the lung(3.57%)=syndrome of deficiency of spleen-yangand kidney-yang plus phlegm and stasis retention in the lung>syndrome of phlegmretention in the lung (1.79%)=syndrome of deficiency of spleen-yang and kidney-yang=syndrome of deficiency of lung-qi and kidney-qi plus syndrome of phlegm and stasisretention in the lung. The syndrome of deficiency in origin accounts for50.00%,thesyndrome of deficiency in origin and excess in superficiality accounts for35.71%;thesyndrome of excess in superficiality accounts for19.05%.The excess in superficiality are phlegm plus stasis (32.14%)> phlegm(17.86%)>stasis(0%). The syndrome of deficiencyin origin shows the syndrome of deficiency of lung-qi and kidney-qi (35.71%)>syndromeof deficiency of lung-qi and spleen-qi (19.05%)>syndrome of deficiency of lung-qi plusdeficiency of kidney-yang(16.67%)>syndrome of deficiency of lung-qi(7.14%)>syndrome of deficiency of kidney-yang(2.38%),and the lung appears38person/times(67.86%)> the spleen30person/times(53.57%)>the kidney28person/times(50.00%).During acute exacerbation of idiopathic pulmonary fibrosis,there are8kinds ofsyndrome, syndrome of phlegm and stasis retention in the lung(31.82%)>syndrome ofphlegm-heat retention in the lung(18.08%)> syndrome of deficiency of lung-qi andkidney-qi plus syndrome of phlegm and stasis retention in the lung(15.91%)>syndrome ofphlegm retention in the lung(11.36%)>syndrome of deficiency of lung-qi plus phlegm andstasis retention in the lung(9.09%)>syndrome of deficiency of lung-qi and spleen-qi plusheat-phlegm retention in the lung(6.82%)>syndrome of deficiency of spleen-yang andkidney-yang plus phlegm and stasis retention in the lung(4.55%)>syndrome of bloodstasis due to qi deficiency(2.27%).The syndrome of excess in superficiality accounts for61.36%;the syndrome of deficiency in origin and excess in superficiality accounts for38.64%;the syndrome of deficiency in origin accounts for0%.The excess in superficialityshows the phlegm plus stasis(61.37%)>phlegm(36.36%)> stasis(2.27%). The syndrome ofdeficiency in origin shows the syndrome of deficiency of lung-qi and kidney-qi(15.91%)>syndrome of deficiency of lung-qi(9.09%)=syndrome of deficiency of lung-qi andspleen-qi>syndrome of deficiency of spleen-yang and kidney-yang(4.55%). The lungappears44person/times (100%)> the kidney9person/times (20.45%)> the spleen6person/times (13.64%). During remission of idiopathic pulmonary fibrosis, there are9kinds of syndrome, syndrome of deficiency of lung-qi and kidney-qi (27.27%)>syndromeof blood stasis due to qi deficiency(22.73%)> syndrome of deficiency of spleen-yang andkidney-yang(13.64%)> syndrome of phlegm and stasis retention in the lung(11.36%)>syndrome of deficiency of lung-qi and kidney-qi plus syndrome of phlegm and stasisretention in the lung(9.09%)>syndrome of lung and spleen qi and yin deficiency(6.82%)>syndrome of phlegm-heat retention in the lung(4.55%)>syndrome of phlegm retention inthe lung(2.27%)=syndrome of deficiency of lung-qi plus phlegm and stasis retention inthe lung. The syndrome of deficiency in origin accounts for47.73%; the syndrome ofdeficiency in origin plus excess in superficiality accounts for34.09%; the syndrome ofexcess in superficiality accounts for18.18%. The excess in superficiality are phlegm plus stasis (22.73%)=stasis (22.73%)>phlegm (6.82%). The syndrome of deficiency in originshows the syndrome of deficiency of lung-qi and kidney-qi(38.36%)> syndrome ofdeficiency of lung-qi and spleen-qi(22.73%)> syndrome of deficiency of spleen-yangand kidney-yang(13.64%)>syndrome of lung and spleen qi and yin deficiency (6.82%)>syndrome of deficiency of lung-qi(2.27%). The lung appears38person/times (86.36%)>the kidney22person/times (50.00%)>the spleen19person/times (43.18%).Conclusion:In acute exacerbation of asthma, there is more syndrome of excess in superficialityas combined with other syndrome and the syndromes of deficiency in origin are less. Theexcess in superficiality are phlegm>phlegm plus stasis; the deficiency in origin is mainlyabout lung, spleen and kidney (deficiency of lung> deficiency of kidney>deficiency ofspleen). In remission of asthma, there are more syndromes of deficiency in origin ascombined with other syndromes and the syndromes of excess in superficiality are less.The deficiency in origin is lung, spleen and kidney multi deficiency and the head ofsyndrome is deficiency of lung-qi plus kidney-qi. The excess in superficiality are phlegm=phlegm plus stasis. Compared with acute exacerbation, phlegm and stasis are reducedand the syndromes of deficiency in origin are increased. The deficiency in origin ismainly about the increasing of deficiency of lung-qi, spleen-qi, kidney-qi andkidney-yang.In acute exacerbation of COPD, there is more syndrome of excess in superficiality ascombined with other syndrome and the syndromes of deficiency in origin are less. Theexcess in superficiality are phlegm plus stasis>phlegm; the deficiency in origin is lung,spleen and kidney multi deficiency and deficiency of lung-qi, kidney-qi, spleen-yang andkidney-yang taking the most part. In remission of COPD, there are more syndromes ofdeficiency in origin as combined with other syndromes and the syndromes of excess insuperficiality are less. The deficiency in origin is lung, spleen and kidney multi deficiencyand the head of syndrome is deficiency of lung-qi plus kidney-qi. The excess insuperficiality are phlegm plus stasis>phlegm. Compared with acute exacerbation, phlegmand stasis are reduced and the syndromes of deficiency in origin are increased. Thedeficiency in origin is mainly about the increasing of deficiency of lung-qi, spleen-qi,kidney-qi and kidney-yang. In acute exacerbation of idiopathic pulmonary fibrosis, there is more syndromes ofexcess in superficiality as combined with other syndrome and the syndromes ofdeficiency in origin are less. The excess in superficiality are phlegm plus stasis>phlegm>stasis; the deficiency in origin is lung, spleen and kidney multi deficiency and the head isdeficiency of lung-qi and kidney-qi. In remission of idiopathic pulmonary fibrosis, thereare more syndromes of deficiency in origin as combined with other syndromes and thesyndromes of excess in superficiality are less. The deficiency in origin is lung, spleen andkidney multi deficiency and the head of syndrome is deficiency of lung-qi plus kidney-qi.The excess in superficiality are phlegm plus stasis> stasis>phlegm. Compared with acuteexacerbation, phlegm and stasis are reduced and the syndromes of deficiency in origin areincreased. The deficiency in origin is mainly about the increasing of deficiency of lung-qi,spleen-qi, kidney-qi, kidney-yang and both lung and spleen qi yin deficiency.Under the control of Yin-pathogenic factor, the three diseases all shows moresyndromes of excess in superficiality as combined with other syndromes and thesyndromes of deficiency in origin are less in acute exacerbation. The excess insuperficiality are mainly about phlegm plus stasis and phlegm and the deficiency in originare lung, spleen and kidney multi deficiency. In remission, there are more syndromes ofdeficiency in origin as combined with other syndromes and the syndromes of excess insuperficiality are less. The excess in superficiality are mainly about phlegm plus stasisand stasis and the deficiency in origin is lung-qi plus spleen-qi deficiency. Compared withacute exacerbation, phlegm and stasis are reduced and the deficiency of lung-qi, spleen-qiand kidney-qi are increasing.Under the control of Yin-pathogenic factor, there are some common characteristicand it indicates that the pathogenesis about the three diseases are deficiency in origin andexcess in superficiality. Phlegm and stasis are visible pathogenic factors so it can blockthe qi activity easily and we should take care of the qi of zang-fu viscera intensively. It isjust to say the uprightness exists in your heart, so the evil won’t disturb you. The qi isstrong and the pathogenic factors can be wiped easily and it can prevent progress ofdisease as well. The results show the important of mutual generation and restriction oforgan zang-fu viscera in the development of diseases because the mother of the kidney islung and the lung is spleen, so if the lung gets illness it can transport to it’s mother and (or)it can consume the son’s health. So the kidney and (or) spleen become illness at the end,and that we should pay more attention to this phenomenon during our clinical works.